Presentation Title

Bulk and Particle Level Characteristics of Processed and Unprocessed Powders

Start Date

November 2016

End Date

November 2016

Location

Surge 173

Type of Presentation

Oral Talk

Abstract

In the pharmaceutical industry, the flow characteristics of a powder are an important consideration when producing a capsule or a tablet. Powders that have a low or non-uniform flow pattern can aggregate and cause complications when ingested. Coating the powders with nanoparticles can alter their characteristics to eliminate these complications. The powders examined in this study were ibuprofen and ascorbic acid in combination with either a hydrophobic or hydrophilic coating. The particles were coated using a novel continuous process that involved a rotator that mixed the particles with the coating, and a milling machine that coated the particles. The flow characteristics of the powders were quantified by measuring the bulk density and mass flow rate of the samples. Level of coating was analyzed visually with SEM images. The results indicated that the novel process was indeed capable of coating the particles and that the coatings improved overall bulk flow of ibuprofen. Additionally, it was determined that the Ibuprofen/hydrophobic coating combination exhibited the most uniform surface coverage and best flow properties with respect to the other combinations.

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Nov 12th, 11:30 AM Nov 12th, 11:45 AM

Bulk and Particle Level Characteristics of Processed and Unprocessed Powders

Surge 173

In the pharmaceutical industry, the flow characteristics of a powder are an important consideration when producing a capsule or a tablet. Powders that have a low or non-uniform flow pattern can aggregate and cause complications when ingested. Coating the powders with nanoparticles can alter their characteristics to eliminate these complications. The powders examined in this study were ibuprofen and ascorbic acid in combination with either a hydrophobic or hydrophilic coating. The particles were coated using a novel continuous process that involved a rotator that mixed the particles with the coating, and a milling machine that coated the particles. The flow characteristics of the powders were quantified by measuring the bulk density and mass flow rate of the samples. Level of coating was analyzed visually with SEM images. The results indicated that the novel process was indeed capable of coating the particles and that the coatings improved overall bulk flow of ibuprofen. Additionally, it was determined that the Ibuprofen/hydrophobic coating combination exhibited the most uniform surface coverage and best flow properties with respect to the other combinations.