Presentation Title

Ruthenium Polypyridyl Complexes: Synthesis, Spectroscopic Characterization, and Reactivity with CT-DNA

Start Date

November 2016

End Date

November 2016

Location

HUB 268

Type of Presentation

Oral Talk

Abstract

A series of new ruthenium (II) complexes of both chloro- and aqua-forms using terpyridine analogs and a new phenanthroline-type donor ligand have been synthesized and characterized by various spectroscopic techniques (IR, UV, LC-MS, CV). The DNA-binding studies of these ruthenium complexes have been investigated by absorption-titration and competitive-binding analyses. Intrinsic binding constant (Kb) and Stern-Volmer constant (Ksv) were determined for each complex through absorption-titration as well as competitive-binding studies, respectively. The results obtained indicated that the complexes interact strongly with CT-DNA.

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Nov 12th, 2:30 PM Nov 12th, 2:45 PM

Ruthenium Polypyridyl Complexes: Synthesis, Spectroscopic Characterization, and Reactivity with CT-DNA

HUB 268

A series of new ruthenium (II) complexes of both chloro- and aqua-forms using terpyridine analogs and a new phenanthroline-type donor ligand have been synthesized and characterized by various spectroscopic techniques (IR, UV, LC-MS, CV). The DNA-binding studies of these ruthenium complexes have been investigated by absorption-titration and competitive-binding analyses. Intrinsic binding constant (Kb) and Stern-Volmer constant (Ksv) were determined for each complex through absorption-titration as well as competitive-binding studies, respectively. The results obtained indicated that the complexes interact strongly with CT-DNA.