Presentation Title

Analyzing medulla activity to determine breathing regularity within Sprague-Dawley rat pups

Start Date

November 2016

End Date

November 2016

Location

Surge 171

Type of Presentation

Oral Talk

Abstract

Medulla activity was analyzed to determine breathing regularity within Sprague-Dawley rat pups to assist in early detection of irregular breathing in perinatal infants. The hypoglossal nerve and nTS of the medulla were analyzed in response to various factors. The effects of ifenprodil (NMDA antagonist) on NMDA receptors within the hypoglossal nerve of the brain stem were examined. Additionally, EPSC recordings of the effects of the cytokine IL1β upon inspiratory neurons from Sprague Dawley rat pups were analyzed. The addition of the cytokine IL1β simulates an induced respiratory infection, and then the action potential of the cell is measured. Biomedical Analysis Software Suite (BASS) is a program that was designed to analyze wave data. We developed novel functions that were included in BASS to analyze the specific types of wave data found in this project.


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Nov 12th, 3:00 PM Nov 12th, 3:15 PM

Analyzing medulla activity to determine breathing regularity within Sprague-Dawley rat pups

Surge 171

Medulla activity was analyzed to determine breathing regularity within Sprague-Dawley rat pups to assist in early detection of irregular breathing in perinatal infants. The hypoglossal nerve and nTS of the medulla were analyzed in response to various factors. The effects of ifenprodil (NMDA antagonist) on NMDA receptors within the hypoglossal nerve of the brain stem were examined. Additionally, EPSC recordings of the effects of the cytokine IL1β upon inspiratory neurons from Sprague Dawley rat pups were analyzed. The addition of the cytokine IL1β simulates an induced respiratory infection, and then the action potential of the cell is measured. Biomedical Analysis Software Suite (BASS) is a program that was designed to analyze wave data. We developed novel functions that were included in BASS to analyze the specific types of wave data found in this project.