Presentation Title

Antibacterial studies of ZnO nanoparticles irradiated with femtosecond laser light

Start Date

November 2016

End Date

November 2016

Location

HUB 302-#128

Type of Presentation

Poster

Abstract

The primary aim of the Window to the Brain (WttB) project is to provide optical access to the brain via a transparent cranial implant comprised of nanocrystalline yttria-stabilized zirconia. Like any other implant, there are possibilities of infection, biofilm formation, or implant failure due to bacterial adhesion. Therefore, it is necessary to establish non-invasive strategies to combat infection. We suggest the usage of nano and micro particles of Zinc Oxide (ZnO) in conjunction with laser irradiation to take advantage of certain nonlinear optical effects. These include multi-photon emission to induce redox species, which combats infection, and second harmonic generation, which can effectively stimulate photo-drugs. In this study, we used a solution of ZnO nanoparticles as bactericidal agents and femto-second laser light with a wavelength of 1030 nm and an irradiance of 0.6 W/cm2 as an activator agent. Our studies suggest that the use of ZnO nanoparticles inhibit bacterial growth. Laser irradiation treatment alone also offers inhibition of bacterial growth, up to 70%. The incorporation of nanoparticles offers an additional 20% inhibition. The results suggest that laser irradiation increases the redox species generation of nanoparticles, and that the laser induces redox species as well, independent of nanoparticles. Thus, we demonstrate the use of laser light and semiconductor nanoparticles as a potential agent to killing bacteria throughout a transparent ceramic material.

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Nov 12th, 4:00 PM Nov 12th, 5:00 PM

Antibacterial studies of ZnO nanoparticles irradiated with femtosecond laser light

HUB 302-#128

The primary aim of the Window to the Brain (WttB) project is to provide optical access to the brain via a transparent cranial implant comprised of nanocrystalline yttria-stabilized zirconia. Like any other implant, there are possibilities of infection, biofilm formation, or implant failure due to bacterial adhesion. Therefore, it is necessary to establish non-invasive strategies to combat infection. We suggest the usage of nano and micro particles of Zinc Oxide (ZnO) in conjunction with laser irradiation to take advantage of certain nonlinear optical effects. These include multi-photon emission to induce redox species, which combats infection, and second harmonic generation, which can effectively stimulate photo-drugs. In this study, we used a solution of ZnO nanoparticles as bactericidal agents and femto-second laser light with a wavelength of 1030 nm and an irradiance of 0.6 W/cm2 as an activator agent. Our studies suggest that the use of ZnO nanoparticles inhibit bacterial growth. Laser irradiation treatment alone also offers inhibition of bacterial growth, up to 70%. The incorporation of nanoparticles offers an additional 20% inhibition. The results suggest that laser irradiation increases the redox species generation of nanoparticles, and that the laser induces redox species as well, independent of nanoparticles. Thus, we demonstrate the use of laser light and semiconductor nanoparticles as a potential agent to killing bacteria throughout a transparent ceramic material.