Presentation Title

Quantitative Analysis of Common Analgesics via Liquid Chromatography Systems for the Undergraduate Curriculum

Start Date

November 2016

End Date

November 2016

Location

HUB 302-#9

Type of Presentation

Poster

Abstract

Incorporation of research-level instrumentation into the undergraduate curriculum is turning out to be critical as most chemistry careers require advanced technical skills and knowledge. The overarching goal of this project is to develop an analytical experiment for the quantitative analysis of analgesics via research-level instrumentation, such as the Liquid Chromatography Variable Wavelength Detector (LC/VWD) and High-Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (HPLC-QTOF/MS) systems. Analgesics were chosen as the investigatory subject for this experiment not only because they are easily obtainable, but also because most undergraduate students are familiar with and interested in this class of drugs. At this time we have been successful in developing methods of preparation for acetaminophen, aspirin, and caffeine standards, which have resulted in calibration curves with high linearity using the LC/VWD. Additionally, we have been successful in developing methods for the quantitative analysis of store purchased analgesic tablets, which have resulted in a minimum of 90% mass accuracy for acetaminophen, aspirin, and caffeine. In the future, we will run the same analysis using the HPLC-QTOF/MS in order to compare the efficiencies of these liquid chromatography systems. Lastly, we hope to incorporate this analysis into the undergraduate curriculum by expanding this experiment into either Advanced Lab or Analytical Chemistry Lab.

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Nov 12th, 4:00 PM Nov 12th, 5:00 PM

Quantitative Analysis of Common Analgesics via Liquid Chromatography Systems for the Undergraduate Curriculum

HUB 302-#9

Incorporation of research-level instrumentation into the undergraduate curriculum is turning out to be critical as most chemistry careers require advanced technical skills and knowledge. The overarching goal of this project is to develop an analytical experiment for the quantitative analysis of analgesics via research-level instrumentation, such as the Liquid Chromatography Variable Wavelength Detector (LC/VWD) and High-Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (HPLC-QTOF/MS) systems. Analgesics were chosen as the investigatory subject for this experiment not only because they are easily obtainable, but also because most undergraduate students are familiar with and interested in this class of drugs. At this time we have been successful in developing methods of preparation for acetaminophen, aspirin, and caffeine standards, which have resulted in calibration curves with high linearity using the LC/VWD. Additionally, we have been successful in developing methods for the quantitative analysis of store purchased analgesic tablets, which have resulted in a minimum of 90% mass accuracy for acetaminophen, aspirin, and caffeine. In the future, we will run the same analysis using the HPLC-QTOF/MS in order to compare the efficiencies of these liquid chromatography systems. Lastly, we hope to incorporate this analysis into the undergraduate curriculum by expanding this experiment into either Advanced Lab or Analytical Chemistry Lab.