Presentation Title

Trazodone Hydrochloride Administration to Mitigate Laboratory Rabbit (Oryctolagus cuniculus) Aggression

Start Date

November 2016

End Date

November 2016

Location

HUB 302-#75

Type of Presentation

Poster

Abstract

Aggressive behavior in laboratory rabbits (Oryctolagus cuniculus) can make it difficult for them to be socialized and/or housed together despite the documented benefits of social enrichment. Practically sedation is sometimes necessary to facilitate handling and minimize both stress and injuries. Trazodone hydrochloride (TZN) is a selective serotonin antagonist and serotonin reuptake inhibitor which has been used to treat aggression and anxiety in humans, dogs and cats, but has not been used therapeutically in rabbits. We developed a double-blind, placebo-controlled, randomized crossover study to evaluate the effect of one time 10 mg/kg oral TZN treatment on New Zealand laboratory rabbit doe sedation and agonistic/aggressive behaviors. Fasted animals (n =18) are examined by a veterinarian, in addition to assessing normal health parameters each animal is scored on their level of sedation/compliance prior to receiving either TZN or an equivalent volume of placebo. Each rabbit is monitored and their activity and behaviors are tracked using an ethogram. After three hours (time of maximum concentration) the animals are reexamined by a veterinarian and their level of sedation is again scored. Each rabbit is then placed in a new cage with a foreign rabbit where their behavior is again monitored and scored including the number, duration and latency of onset for agonistic behaviors. Following at least a 72-hour washout period the process is repeated, those animals who had received the placebo now receive the TZN and vice versa. The veterinarian and all examiners are blinded to the treatment groups. Preliminary results will be discussed.

This document is currently not available here.

Share

COinS
 
Nov 12th, 4:00 PM Nov 12th, 5:00 PM

Trazodone Hydrochloride Administration to Mitigate Laboratory Rabbit (Oryctolagus cuniculus) Aggression

HUB 302-#75

Aggressive behavior in laboratory rabbits (Oryctolagus cuniculus) can make it difficult for them to be socialized and/or housed together despite the documented benefits of social enrichment. Practically sedation is sometimes necessary to facilitate handling and minimize both stress and injuries. Trazodone hydrochloride (TZN) is a selective serotonin antagonist and serotonin reuptake inhibitor which has been used to treat aggression and anxiety in humans, dogs and cats, but has not been used therapeutically in rabbits. We developed a double-blind, placebo-controlled, randomized crossover study to evaluate the effect of one time 10 mg/kg oral TZN treatment on New Zealand laboratory rabbit doe sedation and agonistic/aggressive behaviors. Fasted animals (n =18) are examined by a veterinarian, in addition to assessing normal health parameters each animal is scored on their level of sedation/compliance prior to receiving either TZN or an equivalent volume of placebo. Each rabbit is monitored and their activity and behaviors are tracked using an ethogram. After three hours (time of maximum concentration) the animals are reexamined by a veterinarian and their level of sedation is again scored. Each rabbit is then placed in a new cage with a foreign rabbit where their behavior is again monitored and scored including the number, duration and latency of onset for agonistic behaviors. Following at least a 72-hour washout period the process is repeated, those animals who had received the placebo now receive the TZN and vice versa. The veterinarian and all examiners are blinded to the treatment groups. Preliminary results will be discussed.