Presentation Title

Synthesis and X-ray Crystal Structure Studies of Dinitrosyl Iron Complexes based on 1, 10 - Phenanthroline Derivatives

Start Date

November 2016

End Date

November 2016

Location

HUB 302-#12

Type of Presentation

Poster

Abstract

Nitric oxide has many significant roles in biology that include vasodilation, penile erection, host immunity, and neurotransmission. Nitric oxides are normally associated with the heme groups, however, non-heme groups have been gaining popularity in recent times. The rise in attention towards non-heme groups is attributed to the recent discoveries that nitric oxides play a greater role in biological applications aside from hemoglobin. By coordinating select ligands with iron dinitrosyl dicarbonyl, many different compounds and derivatives can be prepared for potential biological applications. The Three dinitrosyl iron complexes (DNICs) being studied here involve the following ligands, respectively: 2, 9-dimethyl-1, 10-phenanthroline (Ligand 1), 3, 4, 7, 8-tetramethyl-1, 10-phenanthroline (Ligand 2), and 2, 9-dimethyl-4, 7-diphenyl-1, 10-phenanthroline (Ligand 3). All three products synthesized contain derivatives of 1, 10-phenanthroline thus were prepared in a similar fashion. In a septum capped vial a mole ratio of 1:1 of ligand and the non-heme iron complex were immersed into 3 mL of DCM for Products 1 and 2, and 3 mL of DMSO for Product 3 for 72 hrs at room temperature to precipitate black single crystals. The crystal products were studied using NMR, IR, UV/vis and X-ray Diffraction. The IR displayed nitrosyl peaks at 1610 cm-1 and 1684 cm-1 for Product 1, 1631 cm-1 and 1686 cm-1 for Product 2, and 1628 cm-1 and 1671 cm-1 for Product 3. The UV/vis absorption max wavelength was found to be 270 nm with a molar absorptivity of L/mol*cm for Product 1.

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Nov 12th, 4:00 PM Nov 12th, 5:00 PM

Synthesis and X-ray Crystal Structure Studies of Dinitrosyl Iron Complexes based on 1, 10 - Phenanthroline Derivatives

HUB 302-#12

Nitric oxide has many significant roles in biology that include vasodilation, penile erection, host immunity, and neurotransmission. Nitric oxides are normally associated with the heme groups, however, non-heme groups have been gaining popularity in recent times. The rise in attention towards non-heme groups is attributed to the recent discoveries that nitric oxides play a greater role in biological applications aside from hemoglobin. By coordinating select ligands with iron dinitrosyl dicarbonyl, many different compounds and derivatives can be prepared for potential biological applications. The Three dinitrosyl iron complexes (DNICs) being studied here involve the following ligands, respectively: 2, 9-dimethyl-1, 10-phenanthroline (Ligand 1), 3, 4, 7, 8-tetramethyl-1, 10-phenanthroline (Ligand 2), and 2, 9-dimethyl-4, 7-diphenyl-1, 10-phenanthroline (Ligand 3). All three products synthesized contain derivatives of 1, 10-phenanthroline thus were prepared in a similar fashion. In a septum capped vial a mole ratio of 1:1 of ligand and the non-heme iron complex were immersed into 3 mL of DCM for Products 1 and 2, and 3 mL of DMSO for Product 3 for 72 hrs at room temperature to precipitate black single crystals. The crystal products were studied using NMR, IR, UV/vis and X-ray Diffraction. The IR displayed nitrosyl peaks at 1610 cm-1 and 1684 cm-1 for Product 1, 1631 cm-1 and 1686 cm-1 for Product 2, and 1628 cm-1 and 1671 cm-1 for Product 3. The UV/vis absorption max wavelength was found to be 270 nm with a molar absorptivity of L/mol*cm for Product 1.