Presentation Title

Comparison of heart phenotypes between short-lived and long-lived populations of Drosophila melanogaster

Start Date

November 2016

End Date

November 2016

Location

HUB 302-125

Type of Presentation

Poster

Abstract

The function of the heart is vulnerable to diseases and dysfunction in humans and also in the model organism, Drosophila melanogaster. Heart function was compared among 18 fly populations that differ in longevity: five populations selected for accelerated development (ACO1-5), which are short-lived, along with their longer-lived control populations (CO1-5), and four populations selected for delayed reproduction (O1-4), which are long-lived, along with their shorter-lived control populations (B1-4). Heart failure rates, heart function phenotypes, and fecundity were measured using various assays. Results showed that laboratory selection for shorter-lived populations of D. melanogaster led to higher percentages of heart failure, shortened heart periods, decreased diastolic intervals, and lower fecundity levels. In general, comparison of heart function phenotypes of shorter-lived populations of D. melanogaster, ACO and B, had decreased heart function compared to their longer-lived counterparts, CO and O, respectively. This suggests that evolutionary adaptations change allele frequencies that affect heart function, so further research should show interest in locating the specific loci that affect heart function.

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Comparison of heart phenotypes between short-lived and long-lived populations of Drosophila melanogaster

HUB 302-125

The function of the heart is vulnerable to diseases and dysfunction in humans and also in the model organism, Drosophila melanogaster. Heart function was compared among 18 fly populations that differ in longevity: five populations selected for accelerated development (ACO1-5), which are short-lived, along with their longer-lived control populations (CO1-5), and four populations selected for delayed reproduction (O1-4), which are long-lived, along with their shorter-lived control populations (B1-4). Heart failure rates, heart function phenotypes, and fecundity were measured using various assays. Results showed that laboratory selection for shorter-lived populations of D. melanogaster led to higher percentages of heart failure, shortened heart periods, decreased diastolic intervals, and lower fecundity levels. In general, comparison of heart function phenotypes of shorter-lived populations of D. melanogaster, ACO and B, had decreased heart function compared to their longer-lived counterparts, CO and O, respectively. This suggests that evolutionary adaptations change allele frequencies that affect heart function, so further research should show interest in locating the specific loci that affect heart function.