Presentation Title

Preparation of polymeric nanospheres for drug delivery

Start Date

November 2016

End Date

November 2016

Location

HUB 302-64

Type of Presentation

Poster

Abstract

The majority of standard therapy for cancer can have cytotoxic effects on normal cells for the patient. Therefore, cancer-targeted therapy that works through both active and passive targeting is currently being investigated. Passive targeting occurs when the nanocarrier takes advantage of the increased permeability of vessels and ineffective lymphatic clearance of the tumor (EPR effect: Enhanced permeability and retention effect). Poly-lactic-co-glycolic acid (PLGA) is a promising copolymer for producing nanoparticles for drug delivery, being biodegradable, biocompatible and FDA approved. However, current anti-cancer drugs utilizing PLGA form microspheres, and thus are unable to take advantage of the EPR effect on the tumor. In this experiment, Paclitaxel-loaded PLGA nanospheres coated with PVA (poly-vinyl alcohol) were prepared by emulsion method. Additionally, these nanospheres were characterized using SEM/TEM and size distribution was analyzed using ImageJ. The majority of produced nanospheres were found to have an average diameter in the range of 101-200 nm and presented a smooth surface and spherical shape. Therefore, these drug-loaded nanospheres have the potential to reach tumoral tissue and reduce off-target effects via passive targeting.

Keywords: cancer-targeted therapy, PLGA, Paclitaxel, nanospheres, emulsion.

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Nov 12th, 1:00 PM Nov 12th, 2:00 PM

Preparation of polymeric nanospheres for drug delivery

HUB 302-64

The majority of standard therapy for cancer can have cytotoxic effects on normal cells for the patient. Therefore, cancer-targeted therapy that works through both active and passive targeting is currently being investigated. Passive targeting occurs when the nanocarrier takes advantage of the increased permeability of vessels and ineffective lymphatic clearance of the tumor (EPR effect: Enhanced permeability and retention effect). Poly-lactic-co-glycolic acid (PLGA) is a promising copolymer for producing nanoparticles for drug delivery, being biodegradable, biocompatible and FDA approved. However, current anti-cancer drugs utilizing PLGA form microspheres, and thus are unable to take advantage of the EPR effect on the tumor. In this experiment, Paclitaxel-loaded PLGA nanospheres coated with PVA (poly-vinyl alcohol) were prepared by emulsion method. Additionally, these nanospheres were characterized using SEM/TEM and size distribution was analyzed using ImageJ. The majority of produced nanospheres were found to have an average diameter in the range of 101-200 nm and presented a smooth surface and spherical shape. Therefore, these drug-loaded nanospheres have the potential to reach tumoral tissue and reduce off-target effects via passive targeting.

Keywords: cancer-targeted therapy, PLGA, Paclitaxel, nanospheres, emulsion.