Presentation Title

Investigation of degradation properties of nmHA coated Magnesium for Orthopedic Application

Faculty Mentor

Jiajia Lin, Dr. Huinan Liu

Start Date

17-11-2018 8:30 AM

End Date

17-11-2018 10:30 AM

Location

HARBESON 23

Session

POSTER 1

Type of Presentation

Poster

Subject Area

engineering_computer_science

Abstract

Magnesium (Mg) and its alloys have showed attractive biocompatibility and mechanical properties, which is favorable for orthopaedic applications. However, the fast degradation of Mg in physiological solutions, which involves fast release of hydrogen gas and increased of pH, restricts its usage from medical implants applications. In addition, implants infection is also a main issues that results in implant failure. Hydroxyapatite nanoparticles (nHA) has showed better bioresorbability and enhanced osteoblast adhesion and proliferation. Gentamicin, a antibiotic that actively against a wide range of bacterial infections, was mixed with HA nanoparticles to improved the antimicrobial property. In this study, mHA was pre-deposited on Mg beads, followed by the deposition of nHA with different concentrations of gentamicin (10 wt.%, 20 wt.%, 30 wt.%), using a transonic particles acceleration deposition process (TPA). The samples are referred to nmHA, nmHA_1G, nmHA_2G, nmHA_3G. The degradation property in vitro of these samples were analyzed by immersing in revised simulated body fluid (rSBF) for 6 weeks. nmHA showed the least mass change (final/initial) among all groups of samples after 6 weeks of immersion, and the corresponding pH of the cultured media at each time points showed the lowest.

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Nov 17th, 8:30 AM Nov 17th, 10:30 AM

Investigation of degradation properties of nmHA coated Magnesium for Orthopedic Application

HARBESON 23

Magnesium (Mg) and its alloys have showed attractive biocompatibility and mechanical properties, which is favorable for orthopaedic applications. However, the fast degradation of Mg in physiological solutions, which involves fast release of hydrogen gas and increased of pH, restricts its usage from medical implants applications. In addition, implants infection is also a main issues that results in implant failure. Hydroxyapatite nanoparticles (nHA) has showed better bioresorbability and enhanced osteoblast adhesion and proliferation. Gentamicin, a antibiotic that actively against a wide range of bacterial infections, was mixed with HA nanoparticles to improved the antimicrobial property. In this study, mHA was pre-deposited on Mg beads, followed by the deposition of nHA with different concentrations of gentamicin (10 wt.%, 20 wt.%, 30 wt.%), using a transonic particles acceleration deposition process (TPA). The samples are referred to nmHA, nmHA_1G, nmHA_2G, nmHA_3G. The degradation property in vitro of these samples were analyzed by immersing in revised simulated body fluid (rSBF) for 6 weeks. nmHA showed the least mass change (final/initial) among all groups of samples after 6 weeks of immersion, and the corresponding pH of the cultured media at each time points showed the lowest.