Presentation Title

Repurposing and Combination of an Anthelmintic and an Antifungal to treat Acinetobacter baumannii Infections

Faculty Mentor

Mikhail Martchenko

Start Date

17-11-2018 8:30 AM

End Date

17-11-2018 10:30 AM

Location

CREVELING 29

Session

POSTER 1

Type of Presentation

Poster

Subject Area

biological_agricultural_sciences

Abstract

The rising prevalence of multidrug-resistant hospital-acquired infections has increased the need for new antibacterial agents. In this study, a library of 1500 FDA-approved drugs was screened against A. calcoaceticus, a surrogate for the multidrug-resistant A. baumannii. Three compounds were found to have previously undiscovered antibacterial properties against A. calcoaceticus: X, an antifungal, Y, an anthelmintic, and Z, an analogue of Y. These three drugs were tested against a broad spectrum of Gram-positive and Gram-negative bacteria, and were confirmed to have broad-spectrum antibacterial properties. Combinations of these three drugs were tested broad-spectrum, and a novel combination therapy with synergistic effects was discovered. It is suggested that the three drugs and combination therapy be tested in vivo and subsequently used to combat hospital-acquired infections, including A. baumannii.

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Nov 17th, 8:30 AM Nov 17th, 10:30 AM

Repurposing and Combination of an Anthelmintic and an Antifungal to treat Acinetobacter baumannii Infections

CREVELING 29

The rising prevalence of multidrug-resistant hospital-acquired infections has increased the need for new antibacterial agents. In this study, a library of 1500 FDA-approved drugs was screened against A. calcoaceticus, a surrogate for the multidrug-resistant A. baumannii. Three compounds were found to have previously undiscovered antibacterial properties against A. calcoaceticus: X, an antifungal, Y, an anthelmintic, and Z, an analogue of Y. These three drugs were tested against a broad spectrum of Gram-positive and Gram-negative bacteria, and were confirmed to have broad-spectrum antibacterial properties. Combinations of these three drugs were tested broad-spectrum, and a novel combination therapy with synergistic effects was discovered. It is suggested that the three drugs and combination therapy be tested in vivo and subsequently used to combat hospital-acquired infections, including A. baumannii.