Presentation Title

The Effects of Combining Resveratrol with Cisplatin to Treat Leukemia

Faculty Mentor

Hector Valenzuela

Start Date

17-11-2018 8:30 AM

End Date

17-11-2018 10:30 AM

Location

CREVELING 7

Session

POSTER 1

Type of Presentation

Poster

Subject Area

biological_agricultural_sciences

Abstract

The Effects of Combining Resveratrol with Cisplatin to Treat Leukemia

According to the Leukemia and Lymphoma Society, leukemia was ranked as the sixth most common cause of cancer deaths in men in women. Currently, one of the most common methods used to treat this kind of cancer is by using a chemotherapy treatment that involves a drug called cisplatin. Even though this drug is effective as a cancer treatment, it unfortunately causes many damaging side effects to the patient receiving treatment and hinder the patient’s post treatment recovery because normal lung cells are also heavily damaged. Since natural-based chemicals such as resveratrol have been shown to be promising cancer inhibitors in studies involving mice and do not have damaging side effects, this compound will be used in tandem with the cisplatin to see if the combination of these compounds is more effective in killing cancer cells. Our objective is to reduce the concentration of 2uM cisplatin when combined with 10uM resveratrol but maintain the same level of cell death. To determine the effectiveness of our goal, Jurkats cells were treated with the compounds and apoptosis was measured using flow cytometry. Our results thus far indicate the resveratrol and cisplatin can both kill Jurakts cells alone (20% dead resveratrol and 34% cisplatin) or combined (44% cisplatin/resveratrol). We are currently working on reducing the levels of cisplatin with different levels of resveratrol in order to determine the optimal range of cell death and avoid the harmful side effects of cisplatin.

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Nov 17th, 8:30 AM Nov 17th, 10:30 AM

The Effects of Combining Resveratrol with Cisplatin to Treat Leukemia

CREVELING 7

The Effects of Combining Resveratrol with Cisplatin to Treat Leukemia

According to the Leukemia and Lymphoma Society, leukemia was ranked as the sixth most common cause of cancer deaths in men in women. Currently, one of the most common methods used to treat this kind of cancer is by using a chemotherapy treatment that involves a drug called cisplatin. Even though this drug is effective as a cancer treatment, it unfortunately causes many damaging side effects to the patient receiving treatment and hinder the patient’s post treatment recovery because normal lung cells are also heavily damaged. Since natural-based chemicals such as resveratrol have been shown to be promising cancer inhibitors in studies involving mice and do not have damaging side effects, this compound will be used in tandem with the cisplatin to see if the combination of these compounds is more effective in killing cancer cells. Our objective is to reduce the concentration of 2uM cisplatin when combined with 10uM resveratrol but maintain the same level of cell death. To determine the effectiveness of our goal, Jurkats cells were treated with the compounds and apoptosis was measured using flow cytometry. Our results thus far indicate the resveratrol and cisplatin can both kill Jurakts cells alone (20% dead resveratrol and 34% cisplatin) or combined (44% cisplatin/resveratrol). We are currently working on reducing the levels of cisplatin with different levels of resveratrol in order to determine the optimal range of cell death and avoid the harmful side effects of cisplatin.