Presentation Title

Synthesis of 5’-Arylamidonucleosides

Faculty Mentor

Dr. Ahmed Awad

Start Date

17-11-2018 12:30 PM

End Date

17-11-2018 2:30 PM

Location

CREVELING 84

Session

POSTER 2

Type of Presentation

Poster

Subject Area

physical_mathematical_sciences

Abstract

Synthesis of six different 5’-arylamidouridine analogs were performed in four steps and confirmed by NMR and LCMS. Six benzoyl chloride derivatives were reacted with cross protected uridine to form amide products at the 5’-carbon of ribose. The degree of bacterial inhibition produced by each substituent will be quantified using six different gram negative and gram positive bacteria. The results of bacterial inhibition will lead to optimization of future compounds. In addition, difficulties encountered in purification by column chromatography and anhydrous technique will be discussed as well as how they were overcome. As the number of antimicrobial resistant bacteria increases, the necessity for novel antibiotics will continue to grow.

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Nov 17th, 12:30 PM Nov 17th, 2:30 PM

Synthesis of 5’-Arylamidonucleosides

CREVELING 84

Synthesis of six different 5’-arylamidouridine analogs were performed in four steps and confirmed by NMR and LCMS. Six benzoyl chloride derivatives were reacted with cross protected uridine to form amide products at the 5’-carbon of ribose. The degree of bacterial inhibition produced by each substituent will be quantified using six different gram negative and gram positive bacteria. The results of bacterial inhibition will lead to optimization of future compounds. In addition, difficulties encountered in purification by column chromatography and anhydrous technique will be discussed as well as how they were overcome. As the number of antimicrobial resistant bacteria increases, the necessity for novel antibiotics will continue to grow.