Presentation Title

Novel Anticoagulants Using Sulfated Dendrons on Virus-like Particles

Faculty Mentor

Andrew Udit

Start Date

17-11-2018 12:30 PM

End Date

17-11-2018 2:30 PM

Location

CREVELING 86

Session

POSTER 2

Type of Presentation

Poster

Subject Area

physical_mathematical_sciences

Abstract

This research project aims to modify the virus, bacteriophage Q, in order to create a safe alternative to heparin that eradicates the current issue of easy accidental overdose. Components of this project include mutating bacteriophage Q in such a way that sulfated ligands can attach, synthesizing multigenerational dendrons with sulfation sites, and attaching these dendrons to the virus coat. After this is accomplished, following work will require measuring the amount of successful new sulfation sites on the virus, evaluating the stability of the new molecule, and using a clotting assay to measure its effectiveness as a heparin alternative. We have currently been successful in synthesizing the first and second generation dendrons. Although sulfation of the second generation dendron has not been successful yet, we have been able to sulfate the first generation dendron through a reaction with pyridine sulfur trioxide and sodium hydroxide run in pyridine.

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Nov 17th, 12:30 PM Nov 17th, 2:30 PM

Novel Anticoagulants Using Sulfated Dendrons on Virus-like Particles

CREVELING 86

This research project aims to modify the virus, bacteriophage Q, in order to create a safe alternative to heparin that eradicates the current issue of easy accidental overdose. Components of this project include mutating bacteriophage Q in such a way that sulfated ligands can attach, synthesizing multigenerational dendrons with sulfation sites, and attaching these dendrons to the virus coat. After this is accomplished, following work will require measuring the amount of successful new sulfation sites on the virus, evaluating the stability of the new molecule, and using a clotting assay to measure its effectiveness as a heparin alternative. We have currently been successful in synthesizing the first and second generation dendrons. Although sulfation of the second generation dendron has not been successful yet, we have been able to sulfate the first generation dendron through a reaction with pyridine sulfur trioxide and sodium hydroxide run in pyridine.