Presentation Title

Binary vs Polar Division in Chlamydia Trachomatis: Imaging Bias and Computational Model

Faculty Mentor

German Enciso

Start Date

17-11-2018 12:30 PM

End Date

17-11-2018 2:30 PM

Location

CREVELING 30

Session

POSTER 2

Type of Presentation

Poster

Subject Area

physical_mathematical_sciences

Abstract

Recent work has been made to determine the reproductive mechanism in Chlamydia— a major sexually transmitted disease. Using different experimental evidence, two groups have reached conflicting conclusions as to whether it divides in a binary fashion, or via polar division through bud formation. We use computational methods to study the bias resulting from measuring cell sizes using 2D slices rather than 3D volumes of the bacteria. We find that this bias can lead to a conclusion of polar division, even when division is binary. Additionally, we implement a recent hypothesis of cell fate regulation through cell size, to demonstrate that experimental data is consistent with binary division.

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Nov 17th, 12:30 PM Nov 17th, 2:30 PM

Binary vs Polar Division in Chlamydia Trachomatis: Imaging Bias and Computational Model

CREVELING 30

Recent work has been made to determine the reproductive mechanism in Chlamydia— a major sexually transmitted disease. Using different experimental evidence, two groups have reached conflicting conclusions as to whether it divides in a binary fashion, or via polar division through bud formation. We use computational methods to study the bias resulting from measuring cell sizes using 2D slices rather than 3D volumes of the bacteria. We find that this bias can lead to a conclusion of polar division, even when division is binary. Additionally, we implement a recent hypothesis of cell fate regulation through cell size, to demonstrate that experimental data is consistent with binary division.