Presentation Title

Gap junctions mediate repulsive cue-dependent food leaving

Faculty Mentor

Gareth Harris

Start Date

17-11-2018 3:00 PM

End Date

17-11-2018 5:00 PM

Location

CREVELING 7

Session

POSTER 3

Type of Presentation

Poster

Subject Area

behavioral_social_sciences

Abstract

Organism’s across the phyla are capable of responding to an array of sensory cues to allow coordinated behavior to occur, completion of daily task and in many organisms is essential for survival.

Despite the appreciation of organisms having the ability to sense many cues and execute the correct decisions and choices. The cellular mechanisms and neural circuits that mediate these behaviors are still not understood. A number of neuronal signaling transmitter systems have been implicated in sensory-mediate locomotory behaviors, including serotonin, dopamine, GABA and glutamate. We investigate the role of an additional types of communication in the nervous system, mediated through gap junctions. Gap junctions have been previously implicated in a variety of behaviors and are shown to be expressed in key areas of the mammalian brain required for sensation, neural processing of sensory information and other critical brain regions associated with executing behavior and modulating the state of the brain. C. elegans contain around 20 genes that are predicted to encode gap-junctions, known as “innexins”. Using a combination of genetics and behavioral analysis to understand the neuronal signaling molecules that regulate sensory dependent behavior. Many of these neuronally expressed genes are important for many aspects of nervous system function and play a role in sensory-dependent locomotor behaviors in C. elegans. In Dr. Harris lab, we examine mutants that lack specific functions of electrical gap junction signaling pathways in a multi-sensory behavioral paradigm, known as, nonanone-dependent food leaving. We will determine if any of these gap junction genes mediate this aversive behavior through genetic manipulation of the worms genome and manipulation of the nervous system. To achieve these goals, I will use genetics, and behavioral analysis in C. elegans to address these questions. These studies will allow potential identification of specific gap junctions in mediating a complex sensory-dependent behavioral process.

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Nov 17th, 3:00 PM Nov 17th, 5:00 PM

Gap junctions mediate repulsive cue-dependent food leaving

CREVELING 7

Organism’s across the phyla are capable of responding to an array of sensory cues to allow coordinated behavior to occur, completion of daily task and in many organisms is essential for survival.

Despite the appreciation of organisms having the ability to sense many cues and execute the correct decisions and choices. The cellular mechanisms and neural circuits that mediate these behaviors are still not understood. A number of neuronal signaling transmitter systems have been implicated in sensory-mediate locomotory behaviors, including serotonin, dopamine, GABA and glutamate. We investigate the role of an additional types of communication in the nervous system, mediated through gap junctions. Gap junctions have been previously implicated in a variety of behaviors and are shown to be expressed in key areas of the mammalian brain required for sensation, neural processing of sensory information and other critical brain regions associated with executing behavior and modulating the state of the brain. C. elegans contain around 20 genes that are predicted to encode gap-junctions, known as “innexins”. Using a combination of genetics and behavioral analysis to understand the neuronal signaling molecules that regulate sensory dependent behavior. Many of these neuronally expressed genes are important for many aspects of nervous system function and play a role in sensory-dependent locomotor behaviors in C. elegans. In Dr. Harris lab, we examine mutants that lack specific functions of electrical gap junction signaling pathways in a multi-sensory behavioral paradigm, known as, nonanone-dependent food leaving. We will determine if any of these gap junction genes mediate this aversive behavior through genetic manipulation of the worms genome and manipulation of the nervous system. To achieve these goals, I will use genetics, and behavioral analysis in C. elegans to address these questions. These studies will allow potential identification of specific gap junctions in mediating a complex sensory-dependent behavioral process.