Presentation Title

Characterization of the Role of Neuropeptide Receptors in a Multisensory-Dependent Decision Making Process

Faculty Mentor

Gareth Harris

Start Date

17-11-2018 3:00 PM

End Date

17-11-2018 5:00 PM

Location

CREVELING 15

Session

POSTER 3

Type of Presentation

Poster

Subject Area

behavioral_social_sciences

Abstract

An environment is often represented by numerous sensory cues. For example, an area containing food can produce both attractive and repulsive cues, which stimulate specific modality pathways and therefore allow an organism to integrate multiple simultaneous pieces of information to coordinate decision-making behavior. Because integrating multiple sensory cues generates a more accurate evaluation of the environment, it provides important adaptive values. Multi-sensory behavior is widely observed in both vertebrate and invertebrate animals. One common characteristic of multi-sensory behavioral responses and decision-making processes is their ability to be modulated by various internal states and contexts, including arousal, sleepiness versus wakefulness, and the motivational or nutritional state of the organism. Neurological diseases, including autism spectrum disorder, Parkinson’s disease, bipolar disorder, depression, schizophrenia, and gambling behaviors, share deficits associated with sensory processing or decision-making when encountering multiple sensory stimuli that evoke certain behavioral choices under normal conditions. We use the nematode model, C. elegans to examine a multi-sensory behavior, where we expose the worm to attractive food and repulsive cues in the form of 2-nonanone and assess food leaving during exposure to this repellant. We examine the role of neuropeptide/neuropeptide receptor signaling in this behavior, through characterizing roles for potential neuropeptide receptors present in the worm in this multi-sensory behavioral paradigm, known as “nonanone-dependent food leaving”. This study will aim to provide more insight into how neuropeptide signaling via neuropeptide receptors shape organisms sensory behavior and we hope help in proving insight into how neuropeptide receptors modulate sensory-dependent decision-making.

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Nov 17th, 3:00 PM Nov 17th, 5:00 PM

Characterization of the Role of Neuropeptide Receptors in a Multisensory-Dependent Decision Making Process

CREVELING 15

An environment is often represented by numerous sensory cues. For example, an area containing food can produce both attractive and repulsive cues, which stimulate specific modality pathways and therefore allow an organism to integrate multiple simultaneous pieces of information to coordinate decision-making behavior. Because integrating multiple sensory cues generates a more accurate evaluation of the environment, it provides important adaptive values. Multi-sensory behavior is widely observed in both vertebrate and invertebrate animals. One common characteristic of multi-sensory behavioral responses and decision-making processes is their ability to be modulated by various internal states and contexts, including arousal, sleepiness versus wakefulness, and the motivational or nutritional state of the organism. Neurological diseases, including autism spectrum disorder, Parkinson’s disease, bipolar disorder, depression, schizophrenia, and gambling behaviors, share deficits associated with sensory processing or decision-making when encountering multiple sensory stimuli that evoke certain behavioral choices under normal conditions. We use the nematode model, C. elegans to examine a multi-sensory behavior, where we expose the worm to attractive food and repulsive cues in the form of 2-nonanone and assess food leaving during exposure to this repellant. We examine the role of neuropeptide/neuropeptide receptor signaling in this behavior, through characterizing roles for potential neuropeptide receptors present in the worm in this multi-sensory behavioral paradigm, known as “nonanone-dependent food leaving”. This study will aim to provide more insight into how neuropeptide signaling via neuropeptide receptors shape organisms sensory behavior and we hope help in proving insight into how neuropeptide receptors modulate sensory-dependent decision-making.