Presentation Title

Validating AUDIT Using Serum Phosphotidylethanol

Faculty Mentor

Wirachin Hoonpongsimanont MD, MS

Start Date

18-11-2017 11:30 AM

End Date

18-11-2017 11:45 AM

Location

9-255

Session

Bio Sciences 1

Type of Presentation

Oral Talk

Subject Area

health_nutrition_clinical_science

Abstract

Alcohol use is a major public health concern due to the health risks that are directly caused by alcohol consumption and exceedingly widespread use. Excessive alcohol use has led to approximately 88000 deaths and was responsible for 1 in 10 deaths in adults between 20 and 64 years of age (CDC 2016). To screen for drinking levels and alcohol dependence, the World Health Organization developed an Alcohol Use Disorders Test (AUDIT). This screening has been implemented at the University of California, Irvine Medical Center Emergency Department. Alcohol biomarkers, such as phosphatidylethanol (PEth), in the blood can determine the amount of alcohol consumed by individuals. PEth has a high sensitivity and detection window making it a prime biomarker to use for alcohol screening. Our study aims to investigate the usefulness of PEth for alcohol screening by comparing it to AUDIT score. We would like to see the correlation between the biochemical test and the self-reported measure to confirm validities of both tests. Furthermore, the benefits and drawbacks of those tests should be considered to evaluate which procedure can be confidently implemented as the standard of care protocol. With a sample size of 43 subjects, the statistics explain that there is a moderate level of significance between AUDIT score and PEth level. There was no significant difference in correlations between genders. Further research can explain deeper into significant trends in the study.

Summary of research results to be presented

Our preliminary results include a sample size of 43 subjects, who enrolled and participated in the research study at the UCI Medical Center Emergency Department. The statistical analysis performed were the Kappa coefficient level and Pearson linear correlation measurements. Using a confidence interval of 95%, there is a statistically significant moderate level of correlation (r =0.37) between AUDIT score and PEth level. There was not a significant difference in correlations between male and female subjects. Further research can explain deeper into significant trends in the study.

This document is currently not available here.

Share

COinS
 
Nov 18th, 11:30 AM Nov 18th, 11:45 AM

Validating AUDIT Using Serum Phosphotidylethanol

9-255

Alcohol use is a major public health concern due to the health risks that are directly caused by alcohol consumption and exceedingly widespread use. Excessive alcohol use has led to approximately 88000 deaths and was responsible for 1 in 10 deaths in adults between 20 and 64 years of age (CDC 2016). To screen for drinking levels and alcohol dependence, the World Health Organization developed an Alcohol Use Disorders Test (AUDIT). This screening has been implemented at the University of California, Irvine Medical Center Emergency Department. Alcohol biomarkers, such as phosphatidylethanol (PEth), in the blood can determine the amount of alcohol consumed by individuals. PEth has a high sensitivity and detection window making it a prime biomarker to use for alcohol screening. Our study aims to investigate the usefulness of PEth for alcohol screening by comparing it to AUDIT score. We would like to see the correlation between the biochemical test and the self-reported measure to confirm validities of both tests. Furthermore, the benefits and drawbacks of those tests should be considered to evaluate which procedure can be confidently implemented as the standard of care protocol. With a sample size of 43 subjects, the statistics explain that there is a moderate level of significance between AUDIT score and PEth level. There was no significant difference in correlations between genders. Further research can explain deeper into significant trends in the study.