Presentation Title

Characterizing Hydrogels Using Vibrating Tube Mass Sensors

Faculty Mentor

William H. Grover

Start Date

18-11-2017 10:00 AM

End Date

18-11-2017 10:15 AM

Location

9-247

Session

Engineering/CS 3

Type of Presentation

Oral Talk

Subject Area

engineering_computer_science

Abstract

Hydrogels have a wide range of applications in the medical field because of their biocompatibility, hydrophilicity, and resemblance to human cells and tissue. But while hydrogels are versatile, characterizing them can become difficult with conventional techniques, which often require slowly drying out the hydrogel to measure its properties like swelling ratio (the fraction of the hydrogel that is water). Our lab recently developed a vibrating tube mass sensor that can measure the mass, volume, and density of microgram-sized objects in fluid with high sensitivity. In this work, we show a novel method of using this sensor to characterize hydrogels. By measuring the buoyant mass of a microgram-sized sample of agarose hydrogel in different fluids, we can determine the mass, volume, density, and porosity of the hydrogel “skeleton” (the non-water framework) with a high precision in just a few minutes without having to dry out or destroy the sample. By providing valuable characterization data about hydrogels faster than existing techniques, our method should accelerate the development of novel hydrogels for important applications in healthcare.

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Nov 18th, 10:00 AM Nov 18th, 10:15 AM

Characterizing Hydrogels Using Vibrating Tube Mass Sensors

9-247

Hydrogels have a wide range of applications in the medical field because of their biocompatibility, hydrophilicity, and resemblance to human cells and tissue. But while hydrogels are versatile, characterizing them can become difficult with conventional techniques, which often require slowly drying out the hydrogel to measure its properties like swelling ratio (the fraction of the hydrogel that is water). Our lab recently developed a vibrating tube mass sensor that can measure the mass, volume, and density of microgram-sized objects in fluid with high sensitivity. In this work, we show a novel method of using this sensor to characterize hydrogels. By measuring the buoyant mass of a microgram-sized sample of agarose hydrogel in different fluids, we can determine the mass, volume, density, and porosity of the hydrogel “skeleton” (the non-water framework) with a high precision in just a few minutes without having to dry out or destroy the sample. By providing valuable characterization data about hydrogels faster than existing techniques, our method should accelerate the development of novel hydrogels for important applications in healthcare.