Presentation Title

Sexual Dimorphism

Faculty Mentor

Parvin Shahrestani

Start Date

18-11-2017 9:59 AM

End Date

18-11-2017 11:00 AM

Location

BSC-Ursa Minor 68

Session

Poster 1

Type of Presentation

Poster

Subject Area

biological_agricultural_sciences

Abstract

In many animal species, females and males vary in physiology, lifespan, and immune function. But the magnitude and direction of the sexual dimorphism in immune function varies greatly, and the genetic and mechanistic bases for the dimorphism are unknown. Here we show that D. melanogaster females are more susceptible than males when inoculated with several strains of the fungal entomopathogen B. bassiana. The sexually dimorphic defense is not exclusively due to barrier defenses and persists even when flies are inoculated by injection. Loss of function mutations of Toll pathway genes remove the dimorphism in susceptibility. Surprisingly, loss of function mutation of relish, a gene in the Imd pathway, also removes the dimorphism, but the dimorphism persists in other Imd pathway mutants. The robust sexual dimorphism in D. melanogaster survival to B. bassiana presents opportunities to further dissect the mechanistic details of the dimorphism, which has applications for biological control of insect vectors of human disease and insect crop pests.

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Nov 18th, 9:59 AM Nov 18th, 11:00 AM

Sexual Dimorphism

BSC-Ursa Minor 68

In many animal species, females and males vary in physiology, lifespan, and immune function. But the magnitude and direction of the sexual dimorphism in immune function varies greatly, and the genetic and mechanistic bases for the dimorphism are unknown. Here we show that D. melanogaster females are more susceptible than males when inoculated with several strains of the fungal entomopathogen B. bassiana. The sexually dimorphic defense is not exclusively due to barrier defenses and persists even when flies are inoculated by injection. Loss of function mutations of Toll pathway genes remove the dimorphism in susceptibility. Surprisingly, loss of function mutation of relish, a gene in the Imd pathway, also removes the dimorphism, but the dimorphism persists in other Imd pathway mutants. The robust sexual dimorphism in D. melanogaster survival to B. bassiana presents opportunities to further dissect the mechanistic details of the dimorphism, which has applications for biological control of insect vectors of human disease and insect crop pests.