Presentation Title

Synthesis of sulfonamide-nucleoside conjugates as potential antimicrobial agents

Faculty Mentor

Dr. Awad

Start Date

18-11-2017 10:00 AM

End Date

18-11-2017 11:00 AM

Location

BSC-Ursa Minor 103

Session

Poster 1

Type of Presentation

Poster

Subject Area

physical_mathematical_sciences

Abstract

Keywords: Nucleoside analogues, Sulfonamide, Therapeutic nucleosides, Mitsunobu, Antibacterial Agents, Antibiotic Resistant

Abstract: Sulfonamide therapeutics have been reported as effective agents for the treatment of bacterial infections and show potential as antiviral agents. With increasing antibiotic resistant bacteria, there is an increasing demand for novel therapeutics to inhibit these pathogens. Nucleoside analogs have also been proposed as efficient antiviral agents as well as antibacterial agents. Coupling of nucleosides with sulfonamide moieties may be an effective way to produce novel molecules to fight such drug resistant bacteria. Synthesis of 5’-sulfonamide-nucleoside derivatives were achieved via Mitsunobu reaction for N-alkylation of primary alcohols. Characterization through NMR and HRMS confirmed the formation of 5’-sulfonamide-nucleosides in high yields. Future directions of our work involve biological testing and evaluation of corresponding 5’-sulfonamide nucleosides for bacterial inhibition.

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Nov 18th, 10:00 AM Nov 18th, 11:00 AM

Synthesis of sulfonamide-nucleoside conjugates as potential antimicrobial agents

BSC-Ursa Minor 103

Keywords: Nucleoside analogues, Sulfonamide, Therapeutic nucleosides, Mitsunobu, Antibacterial Agents, Antibiotic Resistant

Abstract: Sulfonamide therapeutics have been reported as effective agents for the treatment of bacterial infections and show potential as antiviral agents. With increasing antibiotic resistant bacteria, there is an increasing demand for novel therapeutics to inhibit these pathogens. Nucleoside analogs have also been proposed as efficient antiviral agents as well as antibacterial agents. Coupling of nucleosides with sulfonamide moieties may be an effective way to produce novel molecules to fight such drug resistant bacteria. Synthesis of 5’-sulfonamide-nucleoside derivatives were achieved via Mitsunobu reaction for N-alkylation of primary alcohols. Characterization through NMR and HRMS confirmed the formation of 5’-sulfonamide-nucleosides in high yields. Future directions of our work involve biological testing and evaluation of corresponding 5’-sulfonamide nucleosides for bacterial inhibition.