Presentation Title

Antibacterial Studies Of ZnO Nanoparticle Coating On Nc-YSZ Irradiated With Femtosecond Laser Light

Faculty Mentor

Guillermo Aguilar

Start Date

18-11-2017 10:00 AM

End Date

18-11-2017 11:00 AM

Location

BSC-Ursa Minor 97

Session

Poster 1

Type of Presentation

Poster

Subject Area

biological_agricultural_sciences

Abstract

The primary aim of the Window to the Brain (WttB) project is to provide optical access to the brain via a transparent cranial implant comprised of nanocrystalline yttria-stabilized zirconia (nc-YSZ) ceramic. Like in any other implant, there are possibilities of infection, biofilm formation, or implant failure due to bacterial adhesion. Therefore, it is necessary to establish non-invasive strategies to combat infection. Previously, we have used a solution of Zinc Oxide (ZnO) nanoparticles as bactericidal agent and femtosecond laser light as an activator agent. The ZnO nanoparticles interact with this kind of laser light in a nonlinear manner. One of the non-linear optical effects is multi-photon emission to induce redox species and combat infection, and second harmonic generation, which could be used for optical imaging in the future. Our studies suggest that the use of ZnO nanoparticles inhibit bacterial growth. Laser irradiation treatment alone also offers inhibition of bacterial growth, up to 70%. The incorporation of ZnO nanoparticles offers an additional 20% inhibition. Now, we suggest the use of a ZnO nanoparticle antibacterial coating on the nc-YSZ obtained by drop casting method in conjunction with laser irradiation. Transformed Escherichia coli (E. Coli) with pGLO plasmid will be used as a representative, clinically-relevant bacteria to probe the antibacterial effect of the coating. The overall goal is to determine if fs-laser light and semiconductor ZnO nanoparticles have an enhanced potential as a bactericidal procedure when combined and applied through the transparent ceramic implant we have developed.

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Nov 18th, 10:00 AM Nov 18th, 11:00 AM

Antibacterial Studies Of ZnO Nanoparticle Coating On Nc-YSZ Irradiated With Femtosecond Laser Light

BSC-Ursa Minor 97

The primary aim of the Window to the Brain (WttB) project is to provide optical access to the brain via a transparent cranial implant comprised of nanocrystalline yttria-stabilized zirconia (nc-YSZ) ceramic. Like in any other implant, there are possibilities of infection, biofilm formation, or implant failure due to bacterial adhesion. Therefore, it is necessary to establish non-invasive strategies to combat infection. Previously, we have used a solution of Zinc Oxide (ZnO) nanoparticles as bactericidal agent and femtosecond laser light as an activator agent. The ZnO nanoparticles interact with this kind of laser light in a nonlinear manner. One of the non-linear optical effects is multi-photon emission to induce redox species and combat infection, and second harmonic generation, which could be used for optical imaging in the future. Our studies suggest that the use of ZnO nanoparticles inhibit bacterial growth. Laser irradiation treatment alone also offers inhibition of bacterial growth, up to 70%. The incorporation of ZnO nanoparticles offers an additional 20% inhibition. Now, we suggest the use of a ZnO nanoparticle antibacterial coating on the nc-YSZ obtained by drop casting method in conjunction with laser irradiation. Transformed Escherichia coli (E. Coli) with pGLO plasmid will be used as a representative, clinically-relevant bacteria to probe the antibacterial effect of the coating. The overall goal is to determine if fs-laser light and semiconductor ZnO nanoparticles have an enhanced potential as a bactericidal procedure when combined and applied through the transparent ceramic implant we have developed.