Presentation Title

Effects of NAC in enhancing the granulomatous responses against mycobacterial infection

Faculty Mentor

John K. Chan, Viswanath Venketaraman

Start Date

18-11-2017 10:00 AM

End Date

18-11-2017 11:00 AM

Location

BSC-Ursa Minor 39

Session

Poster 1

Type of Presentation

Poster

Subject Area

biological_agricultural_sciences

Abstract

Mycobacterium tuberculosis infection is associated with oxidative stress, redox imbalance and inflammation. N-acetyl-cysteine (NAC) is used in patients with chronic pulmonary diseases including tuberculosis due to its mucolytic and antioxidant activities. Here, we tested whether NAC induces formation of stable and solid granulomas, and enhances effector responses against a BCG (non-virulent M.tb) infection.

Summary of research results to be presented

Our results indicate that BCG infection results in an increase in the levels of free radicals and cytokines such as IL-6, IL-10 and a decrease in the levels of IFN-γ, TNF-α, and rGSH. An increase in levels of rGSH is noted after 15 days during NAC treatment, this indicates that NAC is being converted to GSH and made available to use in cells for ROS control.

This document is currently not available here.

Share

COinS
 
Nov 18th, 10:00 AM Nov 18th, 11:00 AM

Effects of NAC in enhancing the granulomatous responses against mycobacterial infection

BSC-Ursa Minor 39

Mycobacterium tuberculosis infection is associated with oxidative stress, redox imbalance and inflammation. N-acetyl-cysteine (NAC) is used in patients with chronic pulmonary diseases including tuberculosis due to its mucolytic and antioxidant activities. Here, we tested whether NAC induces formation of stable and solid granulomas, and enhances effector responses against a BCG (non-virulent M.tb) infection.