Presentation Title

Gold Cavitands: New Selection Rules for Alkyne Cyclization

Faculty Mentor

Michael P. Schramm

Start Date

18-11-2017 9:59 AM

End Date

18-11-2017 11:00 AM

Location

BSC-Ursa Minor 140

Session

Poster 1

Type of Presentation

Poster

Subject Area

physical_mathematical_sciences

Abstract

Gold Cavitands: New Selection Rules for Alkyne Cyclization Teodora Nedic, Michael P. Schramm, Ph.D Department of Chemistry and Biochemistry, California State University-Long Beach, Long Beach, CA 90840

Gold cavitands and their applications to furthering the understanding of natural enzymatic processes have been a great interest in our lab. Using cavitands with gold functional groups, we expect to find new chemical transformations of small molecules as well as a better understanding of their properties. The experiments are designed to test the cavitand’s performance. The substrate we will be working with contains a carboxylic acid and an alkyne and, upon the influence of the cavitand, we question as to whether it will form a 5-membered or a 6-membered ring. Various analogs of this substrate will be synthesized using basic organic chemistry techniques and will all be tested against the cavitand. We anticipate that the cavitands will behave differently depending on how a given substrate probes the cavitand interior. The results will further our understanding of both gold cavitands and, on a grandeur scale, how enzymes behave with their substrates.

This project is supported in part by RISE (NIH 2R25GM071638-09A1) and NSF RUI (CHE 1708937)

Keywords: Cavitands, enzymes, substrates, synthesis, organic chemistry, supramolecular chemistry, alkyne cyclization, gold, molecules, selection

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Nov 18th, 9:59 AM Nov 18th, 11:00 AM

Gold Cavitands: New Selection Rules for Alkyne Cyclization

BSC-Ursa Minor 140

Gold Cavitands: New Selection Rules for Alkyne Cyclization Teodora Nedic, Michael P. Schramm, Ph.D Department of Chemistry and Biochemistry, California State University-Long Beach, Long Beach, CA 90840

Gold cavitands and their applications to furthering the understanding of natural enzymatic processes have been a great interest in our lab. Using cavitands with gold functional groups, we expect to find new chemical transformations of small molecules as well as a better understanding of their properties. The experiments are designed to test the cavitand’s performance. The substrate we will be working with contains a carboxylic acid and an alkyne and, upon the influence of the cavitand, we question as to whether it will form a 5-membered or a 6-membered ring. Various analogs of this substrate will be synthesized using basic organic chemistry techniques and will all be tested against the cavitand. We anticipate that the cavitands will behave differently depending on how a given substrate probes the cavitand interior. The results will further our understanding of both gold cavitands and, on a grandeur scale, how enzymes behave with their substrates.

This project is supported in part by RISE (NIH 2R25GM071638-09A1) and NSF RUI (CHE 1708937)

Keywords: Cavitands, enzymes, substrates, synthesis, organic chemistry, supramolecular chemistry, alkyne cyclization, gold, molecules, selection