Presentation Title

Investigation of Degradation Behavior of Hydroxyapatite Coated Magnesium

Faculty Mentor

Huinan Liu

Start Date

18-11-2017 10:00 AM

End Date

18-11-2017 11:00 AM

Location

BSC-Ursa Minor 73

Session

Poster 1

Type of Presentation

Poster

Subject Area

engineering_computer_science

Abstract

Magnesium(Mg) alloys have many characteristics that would be useful as biodegradable orthopedic bone screw material such as its osteoconductivity and the similarity of its mechanical properties to cortical bone. Unfortunately, it’s fast degradation rate resolves in complications such as bone screw mechanical failure, local alkalosis, and hypermagnesemia. The degradation rate of Mg bone screw can potentially be reduced with the use of Hydroxyapatite(HA) as a surface coating. HA has the important properties of being biocompatible and aiding in osteoblast functions on top of being able to strengthen Mg’s corrosion resistance. In addition, we incorporated an antibiotic, Gentamicin(Gen), onto HA coating with varied ratio to improve samples antibiotic property. To investigate the degradation behavior, we immersed HA coated Mg samples and controls in revised simulated body fluid (rSBF) under standard cell culture conditions. The characterization is accomplished via photograph of samples, pH change of media, mass change of samples, ion concentration in media, elemental composition of samples, high resolution imaging, and mechanical properties.

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Nov 18th, 10:00 AM Nov 18th, 11:00 AM

Investigation of Degradation Behavior of Hydroxyapatite Coated Magnesium

BSC-Ursa Minor 73

Magnesium(Mg) alloys have many characteristics that would be useful as biodegradable orthopedic bone screw material such as its osteoconductivity and the similarity of its mechanical properties to cortical bone. Unfortunately, it’s fast degradation rate resolves in complications such as bone screw mechanical failure, local alkalosis, and hypermagnesemia. The degradation rate of Mg bone screw can potentially be reduced with the use of Hydroxyapatite(HA) as a surface coating. HA has the important properties of being biocompatible and aiding in osteoblast functions on top of being able to strengthen Mg’s corrosion resistance. In addition, we incorporated an antibiotic, Gentamicin(Gen), onto HA coating with varied ratio to improve samples antibiotic property. To investigate the degradation behavior, we immersed HA coated Mg samples and controls in revised simulated body fluid (rSBF) under standard cell culture conditions. The characterization is accomplished via photograph of samples, pH change of media, mass change of samples, ion concentration in media, elemental composition of samples, high resolution imaging, and mechanical properties.