Presentation Title

PEGylation of Metal-Organic Frameworks as Drug Carriers

Faculty Mentor

Yangyang Liu PhD

Start Date

18-11-2017 10:00 AM

End Date

18-11-2017 11:00 AM

Location

BSC-Ursa Minor 118

Session

Poster 1

Type of Presentation

Poster

Subject Area

physical_mathematical_sciences

Abstract

Metal-organic frameworks (MOFs) are hybrid organic-inorganic materials with high internal surface area. MOFs are synthesized by the solvothermal self-assembly of metal clusters and organic ligands.

The abundant surface area of MOFs facilitates chemical adsorption, demonstrating potential in drug delivery and overcoming challenges in controlled drug release and loading capacity due to functionalizable surfaces and tunable syntheses. Research on the surface modifications of MOFs is underdeveloped. Thus, we aim to study the surface adhesion of the acid-sensitive poly(ethylene glycol) (PEG), known as PEGylation, in pH-responsive drug release. PEGylation introduces enhanced therapeutic properties to drug nanocarriers, such as promoting controlled drug release.

Lázaro and colleagues have reported the encapsulation kinetics and pH-sensitivity of modified UiO-66, a cage-structured MOF.1 We hypothesize that the channel MOF NU-1000, due to larger pore size, will be a more efficient drug carrier MOF and exhibit similar enhanced properties upon PEGylation.

We have synthesized NU-1000, characterizing the organic ligand by NMR and MOF crystallinity by XRD. Surface-modified NU-1000 was prepared by solvent-assisted ligand incorporation of 4-(azidomethyl)benzoic acid, which contains an azide functionality reactive in click chemistry with alkynyl-functionalized PEG derivatives.

The funding for the CSULA LSAMP-BD Cohort XI program is provided by the National Science Foundation under Grant # HRD-1363399.

1 Lázaro, I. A. C. A.; Haddad, S.; Sacca, S.; Orellana-Tavra, C.; Fairen-Jimenez, D.; Forgan, R. S. Chem 2017, 2 (4), 561–578.

Summary of research results to be presented

Future work includes the PEGylation of drug carrier MOFs by alkynyl-functionalized PEG derivatives and investigation of drug encapsulation and pH-responsive release of various cancer drugs in vitro. Results regarding the encapsulation and release kinetics of PEGylated MOFs will be reported; work is still in progress. This research will be extended to similar drug delivery MOFs to compare the effects of PEGylation on MOF pore size and structure.

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Nov 18th, 10:00 AM Nov 18th, 11:00 AM

PEGylation of Metal-Organic Frameworks as Drug Carriers

BSC-Ursa Minor 118

Metal-organic frameworks (MOFs) are hybrid organic-inorganic materials with high internal surface area. MOFs are synthesized by the solvothermal self-assembly of metal clusters and organic ligands.

The abundant surface area of MOFs facilitates chemical adsorption, demonstrating potential in drug delivery and overcoming challenges in controlled drug release and loading capacity due to functionalizable surfaces and tunable syntheses. Research on the surface modifications of MOFs is underdeveloped. Thus, we aim to study the surface adhesion of the acid-sensitive poly(ethylene glycol) (PEG), known as PEGylation, in pH-responsive drug release. PEGylation introduces enhanced therapeutic properties to drug nanocarriers, such as promoting controlled drug release.

Lázaro and colleagues have reported the encapsulation kinetics and pH-sensitivity of modified UiO-66, a cage-structured MOF.1 We hypothesize that the channel MOF NU-1000, due to larger pore size, will be a more efficient drug carrier MOF and exhibit similar enhanced properties upon PEGylation.

We have synthesized NU-1000, characterizing the organic ligand by NMR and MOF crystallinity by XRD. Surface-modified NU-1000 was prepared by solvent-assisted ligand incorporation of 4-(azidomethyl)benzoic acid, which contains an azide functionality reactive in click chemistry with alkynyl-functionalized PEG derivatives.

The funding for the CSULA LSAMP-BD Cohort XI program is provided by the National Science Foundation under Grant # HRD-1363399.

1 Lázaro, I. A. C. A.; Haddad, S.; Sacca, S.; Orellana-Tavra, C.; Fairen-Jimenez, D.; Forgan, R. S. Chem 2017, 2 (4), 561–578.