Presentation Title

The Effect of Essiac's Antioxidant Properties on the Immune System and Cell Proliferation

Faculty Mentor

Sylvia Vetrone

Start Date

18-11-2017 12:30 PM

End Date

18-11-2017 1:30 PM

Location

BSC-Ursa Minor 64

Session

Poster 2

Type of Presentation

Poster

Subject Area

biological_agricultural_sciences

Abstract

Essiac tea is an antioxidant that is touted as a homeopathic cancer treatment. Essiac is made up of four herbs: Arctium lappa, Rumex acetosella, Ulmus rubra and Rheum officinale. As previous studies have demonstrated Essiac’s antioxidant properties to combat DNA damage by reactive oxygen species (ROS), we hypothesize that Essiac tea will also have the capacity to boost an organism’s immune system, by reducing ROS and therefore affect life span. Accordingly, in this study we investigated Essiac’s antioxidant properties on lifespan and ability to withstand oxidative stress on nematode model, Caenorabditis elegans (C. elegans). Similar to previous findings, we found that C. elegans treated with 100% Essiac had a statistical increase in their overall lifespan, and ability to withstand acute oxidative stressed to their control group. In addition, we found that this trend was also maintained when C. elegans were treated with doses as low as 25%, although the differences were not maintained over time. In conjunction with this, our study investigated Essiac’s effect on the lymphoma cancer cell line, RPMI 8226. We hypothesized that Essiac’s antioxidant properties would be able to inhibit cell proliferation in the cell line, similarly to Ottenweller’s experiment who tested cell proliferation on prostate cancer (Ottenweller, Putt, et al. 2004). Through two viability assessments, our results show that at the higher concentrations of Essiac exposure (50-100%), there is trend towards increase cell death. As our findings are very promising, current studies are being conducted to determine the mechanisms through which Essiac is exerting its effects on both C. elegans and various other cancer cell lines.

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Nov 18th, 12:30 PM Nov 18th, 1:30 PM

The Effect of Essiac's Antioxidant Properties on the Immune System and Cell Proliferation

BSC-Ursa Minor 64

Essiac tea is an antioxidant that is touted as a homeopathic cancer treatment. Essiac is made up of four herbs: Arctium lappa, Rumex acetosella, Ulmus rubra and Rheum officinale. As previous studies have demonstrated Essiac’s antioxidant properties to combat DNA damage by reactive oxygen species (ROS), we hypothesize that Essiac tea will also have the capacity to boost an organism’s immune system, by reducing ROS and therefore affect life span. Accordingly, in this study we investigated Essiac’s antioxidant properties on lifespan and ability to withstand oxidative stress on nematode model, Caenorabditis elegans (C. elegans). Similar to previous findings, we found that C. elegans treated with 100% Essiac had a statistical increase in their overall lifespan, and ability to withstand acute oxidative stressed to their control group. In addition, we found that this trend was also maintained when C. elegans were treated with doses as low as 25%, although the differences were not maintained over time. In conjunction with this, our study investigated Essiac’s effect on the lymphoma cancer cell line, RPMI 8226. We hypothesized that Essiac’s antioxidant properties would be able to inhibit cell proliferation in the cell line, similarly to Ottenweller’s experiment who tested cell proliferation on prostate cancer (Ottenweller, Putt, et al. 2004). Through two viability assessments, our results show that at the higher concentrations of Essiac exposure (50-100%), there is trend towards increase cell death. As our findings are very promising, current studies are being conducted to determine the mechanisms through which Essiac is exerting its effects on both C. elegans and various other cancer cell lines.