Presentation Title

Isolation and Characterization of Toxic Alkaloids from Lupinus Albifrons

Faculty Mentor

P. Matthew Joyner

Start Date

18-11-2017 12:30 PM

End Date

18-11-2017 1:30 PM

Location

BSC-Ursa Minor 139

Session

Poster 2

Type of Presentation

Poster

Subject Area

physical_mathematical_sciences

Abstract

Within natural products research, alkaloids remain a promising group of compounds to explore for new medicines due to their extensive biological activities. Thus, exploring unstudied plants in Southern California's diverse biosphere for alkaloids provides great potential for new discoveries. Among these unstudied plants is Lupinus albifrons, a flowering lupine whose alkaloids have demonstrated toxicity when subjected to brine shrimp assays. After demonstrating this bioactivity, the identification of the alkaloid constituents of L. albifrons responsible for toxicity became the focus of this project. Beginning with fractionation, the crude alkaloid extract was separated into several individual components using a combination of silica gel columns and high-performance liquid chromatography. The compounds were then characterized using LCMS and NMR techniques with the identification of the alkaloid anagyrine, a known teratogen, and preliminary data supporting the identification of lupanine. Future work will seek to characterize the toxicity of these compounds individually.

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Nov 18th, 12:30 PM Nov 18th, 1:30 PM

Isolation and Characterization of Toxic Alkaloids from Lupinus Albifrons

BSC-Ursa Minor 139

Within natural products research, alkaloids remain a promising group of compounds to explore for new medicines due to their extensive biological activities. Thus, exploring unstudied plants in Southern California's diverse biosphere for alkaloids provides great potential for new discoveries. Among these unstudied plants is Lupinus albifrons, a flowering lupine whose alkaloids have demonstrated toxicity when subjected to brine shrimp assays. After demonstrating this bioactivity, the identification of the alkaloid constituents of L. albifrons responsible for toxicity became the focus of this project. Beginning with fractionation, the crude alkaloid extract was separated into several individual components using a combination of silica gel columns and high-performance liquid chromatography. The compounds were then characterized using LCMS and NMR techniques with the identification of the alkaloid anagyrine, a known teratogen, and preliminary data supporting the identification of lupanine. Future work will seek to characterize the toxicity of these compounds individually.