Presentation Title

Mitochondrial Fission Determines Th17 Effector Cell Differentiation

Faculty Mentor

Jerome Garcia

Start Date

18-11-2017 12:30 PM

End Date

18-11-2017 1:30 PM

Location

BSC-Ursa Minor 33

Session

Poster 2

Type of Presentation

Poster

Subject Area

behavioral_social_sciences

Abstract

Since their discovery in 2003, the Th17 effector cell lineage has been implicated in a number of central immuno-processes, including mediation of tissue-immune system communication, tumor regression, and the pathogenesis of several autoimmune disorders that together afflict nearly 50 million Americans today. Like other T-Helper lineages, Th17s are derived from CD4+ naïve cells prior to thymic education, differentiate in response to physiological demands, such as the elimination of foreign pathogens in the body. Recent research has elucidated that the differentiation of some t-cells is dependent on morphologic remodeling of their fluid mitochondrial networks, which in turn alters their metabolic programming. While this dynamic is well characterized in immunity conferring t- memory cells, the differentiation energetics of Th17 cells remain poorly understood. As such, the focus of this study is 4 highly conserved GTPase proteins that are known to regulate mitochondrial structure: Opa-1, Mfns-1 and -2, and Drp-1. Our preliminary findings suggest that the protein responsible for initiating mitochondrial fission, Drp-1, plays a central role in determining Th17 cell fate, and may prove to be a valuable target in a number of immune-therapies.

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Nov 18th, 12:30 PM Nov 18th, 1:30 PM

Mitochondrial Fission Determines Th17 Effector Cell Differentiation

BSC-Ursa Minor 33

Since their discovery in 2003, the Th17 effector cell lineage has been implicated in a number of central immuno-processes, including mediation of tissue-immune system communication, tumor regression, and the pathogenesis of several autoimmune disorders that together afflict nearly 50 million Americans today. Like other T-Helper lineages, Th17s are derived from CD4+ naïve cells prior to thymic education, differentiate in response to physiological demands, such as the elimination of foreign pathogens in the body. Recent research has elucidated that the differentiation of some t-cells is dependent on morphologic remodeling of their fluid mitochondrial networks, which in turn alters their metabolic programming. While this dynamic is well characterized in immunity conferring t- memory cells, the differentiation energetics of Th17 cells remain poorly understood. As such, the focus of this study is 4 highly conserved GTPase proteins that are known to regulate mitochondrial structure: Opa-1, Mfns-1 and -2, and Drp-1. Our preliminary findings suggest that the protein responsible for initiating mitochondrial fission, Drp-1, plays a central role in determining Th17 cell fate, and may prove to be a valuable target in a number of immune-therapies.