Presentation Title

Mitochondrial Respiration in Obesity

Faculty Mentor

Jerome Garcia

Start Date

18-11-2017 12:30 PM

End Date

18-11-2017 1:30 PM

Location

BSC-Ursa Minor 32

Session

Poster 2

Type of Presentation

Poster

Subject Area

behavioral_social_sciences

Abstract

Mitochondrial remodeling has recently become a topic of interest as it has been implicated in the progression of diseases. For example, mitochondrial dysfunction and remodeling as an adaptation or acclimatization are the major consequences of chronic alcohol intake. Though this concept has been research in an alcohol model little is known with respect to an obesity model. In this experiment, we focus on obesity and its mitochondrial dynamics. Obesity is an ever-increasing phenomenon in the United States and in the world that leads to a shortened lifespan and increases the chances of getting several more diseases. In our obesity study, mitochondrial respiration was monitored by a Clark-type electrode. The study tests these variables on young and old obese mice. In the old obese mice, the substrate driven respiration increased for glutamate/malate, octanoate, succinate, and glycerol-3-phosphate when compared to control, while the young mice saw no change. Overall the study suggests changes in mitochondrial respiration under the obesity phenotype.

Keywords: Mitochondrial, Remodeling, Respiration, Obesity, Liver

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Nov 18th, 12:30 PM Nov 18th, 1:30 PM

Mitochondrial Respiration in Obesity

BSC-Ursa Minor 32

Mitochondrial remodeling has recently become a topic of interest as it has been implicated in the progression of diseases. For example, mitochondrial dysfunction and remodeling as an adaptation or acclimatization are the major consequences of chronic alcohol intake. Though this concept has been research in an alcohol model little is known with respect to an obesity model. In this experiment, we focus on obesity and its mitochondrial dynamics. Obesity is an ever-increasing phenomenon in the United States and in the world that leads to a shortened lifespan and increases the chances of getting several more diseases. In our obesity study, mitochondrial respiration was monitored by a Clark-type electrode. The study tests these variables on young and old obese mice. In the old obese mice, the substrate driven respiration increased for glutamate/malate, octanoate, succinate, and glycerol-3-phosphate when compared to control, while the young mice saw no change. Overall the study suggests changes in mitochondrial respiration under the obesity phenotype.

Keywords: Mitochondrial, Remodeling, Respiration, Obesity, Liver