Presentation Title

Novel Serotonin 6 Receptor Antagonist And Its Effects On Autistic-Like Behaviors In An Inbred Mouse Strain

Faculty Mentor

Bryce Ryan

Start Date

18-11-2017 12:30 PM

End Date

18-11-2017 1:30 PM

Location

BSC-Ursa Minor 12

Session

Poster 2

Type of Presentation

Poster

Subject Area

behavioral_social_sciences

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder appearing in early childhood and characterized by three core symptoms: restricted, repetitive behaviors (RRB’s), deficits in social interaction as well as deficits in communication. Since the disorder is classified as a spectrum, there are varying severities in the symptoms. The mechanisms underlying the cause of ASD are unknown in most cases, but is likely caused by interactions between various genes and the environment. Selective serotonin reuptake inhibitors (SSRI’s) have historically been used off-label to help treat symptoms of autism, but can have many adverse side effects. By using a novel therapeutic targeting only the 5-HT6 receptor, there is potential to limit these reactions and makes it easier to study behavior as the receptor is confined localized in the CNS. In this study, we aim to determine whether targeting the 5-HT6 receptor will help correct the repetitive and social behaviors seen in the C58/J inbred mouse strain. Intraperitoneal injections of BGC 20-761 at 2.5mg/kg in a 1:1 DMSO:dH2O vehicle or the equivalent volume of only the vehicle was administered to C57BL/6J (control strain) and C58/J mice, and repetitive and social assays were conducted. The social behavior assay used a standard 3-chamber test, and the repetitive behavior assay utilized a regular mouse cage. Preliminary data show the antagonist does not affect the repetitive behaviors of the C57 control strain nor does it cause overt sedative effects. In the near future, social behavior assays and more C58 repetitive behavior data will be collected for analysis.

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Nov 18th, 12:30 PM Nov 18th, 1:30 PM

Novel Serotonin 6 Receptor Antagonist And Its Effects On Autistic-Like Behaviors In An Inbred Mouse Strain

BSC-Ursa Minor 12

Autism spectrum disorder (ASD) is a neurodevelopmental disorder appearing in early childhood and characterized by three core symptoms: restricted, repetitive behaviors (RRB’s), deficits in social interaction as well as deficits in communication. Since the disorder is classified as a spectrum, there are varying severities in the symptoms. The mechanisms underlying the cause of ASD are unknown in most cases, but is likely caused by interactions between various genes and the environment. Selective serotonin reuptake inhibitors (SSRI’s) have historically been used off-label to help treat symptoms of autism, but can have many adverse side effects. By using a novel therapeutic targeting only the 5-HT6 receptor, there is potential to limit these reactions and makes it easier to study behavior as the receptor is confined localized in the CNS. In this study, we aim to determine whether targeting the 5-HT6 receptor will help correct the repetitive and social behaviors seen in the C58/J inbred mouse strain. Intraperitoneal injections of BGC 20-761 at 2.5mg/kg in a 1:1 DMSO:dH2O vehicle or the equivalent volume of only the vehicle was administered to C57BL/6J (control strain) and C58/J mice, and repetitive and social assays were conducted. The social behavior assay used a standard 3-chamber test, and the repetitive behavior assay utilized a regular mouse cage. Preliminary data show the antagonist does not affect the repetitive behaviors of the C57 control strain nor does it cause overt sedative effects. In the near future, social behavior assays and more C58 repetitive behavior data will be collected for analysis.