Presentation Title

The Development of a Separation Technique of 4-Nonylphenol and Creatinine for Urinalysis to Determine a Correlation in Humans

Faculty Mentor

Rebecca Lyons

Start Date

18-11-2017 2:15 PM

End Date

18-11-2017 3:15 PM

Location

BSC-Ursa Minor 91

Session

Poster 3

Type of Presentation

Poster

Subject Area

biological_agricultural_sciences

Abstract

Nonylphenol ethoxylates are used industrially in the manufacturing of pesticides, food packaging films, detergents, lubricants, and similar products. As a result of bacterial degradation nonylphenol ethoxylates are commonly found in the environment as 4-Nonylphenol. 4-Nonylphenol is a known carcinogen and estrogen disruptor; it can enter the human body via inhalation, ingestion, or percutaneously. 4-Nonylphenol detection in urine indicates consistent exposure to products that are manufactured with this compound. Monitoring 4-nonylphenol exposure and its bioaccumulation is beneficial to human health, specifically, in locations where there is widespread usage of pesticides and related products. Urinary concentrations of 4-nonylphenol and creatinine are separated via a liquid extraction and analyzed by Gas Chromatography-Mass Spectrometry and Liquid Chromatography- QTOF, respectively. Urinary creatinine detection operates as a standardizing agent for hydration level; this allows for categorizing the hydration level of the sample population. 4-Nonylphenol has been detected in water samples taken from Idyllwild, Redlands, Big Bear, Lake Perris, and Fresno, all in the state of California, USA. 4-Nonylphenol is bioactive at 3 ppb, therefore, close monitoring of its release into the environment is preferential. This research aims to determine if there is partitioning of this chemical in humans and whether the environment can influence the amount of nonylphenol present in the human body.

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Nov 18th, 2:15 PM Nov 18th, 3:15 PM

The Development of a Separation Technique of 4-Nonylphenol and Creatinine for Urinalysis to Determine a Correlation in Humans

BSC-Ursa Minor 91

Nonylphenol ethoxylates are used industrially in the manufacturing of pesticides, food packaging films, detergents, lubricants, and similar products. As a result of bacterial degradation nonylphenol ethoxylates are commonly found in the environment as 4-Nonylphenol. 4-Nonylphenol is a known carcinogen and estrogen disruptor; it can enter the human body via inhalation, ingestion, or percutaneously. 4-Nonylphenol detection in urine indicates consistent exposure to products that are manufactured with this compound. Monitoring 4-nonylphenol exposure and its bioaccumulation is beneficial to human health, specifically, in locations where there is widespread usage of pesticides and related products. Urinary concentrations of 4-nonylphenol and creatinine are separated via a liquid extraction and analyzed by Gas Chromatography-Mass Spectrometry and Liquid Chromatography- QTOF, respectively. Urinary creatinine detection operates as a standardizing agent for hydration level; this allows for categorizing the hydration level of the sample population. 4-Nonylphenol has been detected in water samples taken from Idyllwild, Redlands, Big Bear, Lake Perris, and Fresno, all in the state of California, USA. 4-Nonylphenol is bioactive at 3 ppb, therefore, close monitoring of its release into the environment is preferential. This research aims to determine if there is partitioning of this chemical in humans and whether the environment can influence the amount of nonylphenol present in the human body.