Presentation Title

Diastereoselective Synthesis of Unnatural Amino Acids via an Auxiliary-Directed Enolate Alkylation

Faculty Mentor

Jeff Cannon

Start Date

18-11-2017 2:15 PM

End Date

18-11-2017 3:15 PM

Location

BSC-Ursa Minor 13

Session

Poster 3

Type of Presentation

Poster

Subject Area

physical_mathematical_sciences

Abstract

Amino acids are an important group of small molecules due to their prevalence in biological systems and useful chiral nature. Unnatural amino acids have become especially sought-after synthetic targets because of both their use in pharmaceuticals and natural products, and as stereochemically rich starting material in stereoselective organic syntheses. We seek to provide a synthetic route to access unnatural amino acids, particularly those with fully substituted or functionalized side chains. Our current studies are examining the diastereoselective alkylation of chiral sulfinamide-bound amino esters to generate derivatives of potential unnatural amino acids.

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Nov 18th, 2:15 PM Nov 18th, 3:15 PM

Diastereoselective Synthesis of Unnatural Amino Acids via an Auxiliary-Directed Enolate Alkylation

BSC-Ursa Minor 13

Amino acids are an important group of small molecules due to their prevalence in biological systems and useful chiral nature. Unnatural amino acids have become especially sought-after synthetic targets because of both their use in pharmaceuticals and natural products, and as stereochemically rich starting material in stereoselective organic syntheses. We seek to provide a synthetic route to access unnatural amino acids, particularly those with fully substituted or functionalized side chains. Our current studies are examining the diastereoselective alkylation of chiral sulfinamide-bound amino esters to generate derivatives of potential unnatural amino acids.