Presentation Title

Differential Sex- and Breed-Dependent Endogenous Oxytocin in Fischer-344 and Sprague Dawley Rats

Faculty Mentor

Dr. Cynthia A. Crawford

Start Date

18-11-2017 2:15 PM

End Date

18-11-2017 3:15 PM

Location

BSC-Ursa Minor 148

Session

Poster 3

Type of Presentation

Poster

Subject Area

behavioral_social_sciences

Abstract

Due to the relatively reduced play behavior of Fischer 344 (F344) rats (Siviy et al., 2003, 2011; Siviy and Panksepp, 2011), previous work in our lab has investigated this strain as a useful autism spectrum disorder (ASD) model. By using a CPP paradigm wherein both F344 and Sprague Dawley (SD) rats showed preference for the scent of their mothers, it was found that intracisternal oxytocin injections altered the behavior of F344 rats, but not of their SD counterparts. The next, and present step in this line of research was to perform an ELISA assay to test for differences in the endogenous levels of oxytocin between the two rat strains. The results provide new insights regarding the use of F344 rats for ASD research.

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Nov 18th, 2:15 PM Nov 18th, 3:15 PM

Differential Sex- and Breed-Dependent Endogenous Oxytocin in Fischer-344 and Sprague Dawley Rats

BSC-Ursa Minor 148

Due to the relatively reduced play behavior of Fischer 344 (F344) rats (Siviy et al., 2003, 2011; Siviy and Panksepp, 2011), previous work in our lab has investigated this strain as a useful autism spectrum disorder (ASD) model. By using a CPP paradigm wherein both F344 and Sprague Dawley (SD) rats showed preference for the scent of their mothers, it was found that intracisternal oxytocin injections altered the behavior of F344 rats, but not of their SD counterparts. The next, and present step in this line of research was to perform an ELISA assay to test for differences in the endogenous levels of oxytocin between the two rat strains. The results provide new insights regarding the use of F344 rats for ASD research.