Presentation Title

Efficacy of Implantable 8-Channel Monopolar Cuff Electrode in a Feline Facial Nerve Paresis Model

Faculty Mentor

Lewis Long

Start Date

18-11-2017 2:15 PM

End Date

18-11-2017 3:15 PM

Location

BSC-Ursa Minor 116

Session

Poster 3

Type of Presentation

Poster

Subject Area

health_nutrition_clinical_science

Abstract

Facial nerve paresis (FNP), a neurological disorder, affects 2.6 million people in the United States, with approximately 480,000 newly diagnosed cases due to Bell’s Palsy alone each year. Pure motor nerves, such as the facial nerve, oftentimes exhibit some form of recovery following injury; however, most suffer from mild to severe loss of motor function, which is typically seen in those who obtain FNP from a stroke. The application of neuroprosthetic devices, namely peripheral nerve interfaces, to augment endogenous function and/or regeneration (e.g., increased neuromuscular junctions) or to restore function artificially has been a successful approach in the treatment of permanent or incomplete FNP. These bioelectric technologies, including nerve cuff electrodes, have already been proved efficacious in improving paretic pathologies and are readily available and employed to treat a variety of disorders in the clinical adjunct setting. This project investigated the novel application of a readily available 8-channel monopolar nerve cuff electrode in a feline model of FNP to selectively stimulate four facial muscles (orbicularis oris, orbicularis oculi, nasalis, and levator auris longus) with direct application to facial re-animation. After analyzing EMG responses versus specific channel stimulation, channel-specific activation of the four different muscles demonstrated selectivity of nasalis and orbicularis oculi in channel 2, selectivity of only orbicularis oculi in channel 6, and selectivity of levator auris longus in channels 11 and 12. The results from this study hold promise for the development of an implantable device to selectively stimulate and activate restricted nerve fiber populations.

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Nov 18th, 2:15 PM Nov 18th, 3:15 PM

Efficacy of Implantable 8-Channel Monopolar Cuff Electrode in a Feline Facial Nerve Paresis Model

BSC-Ursa Minor 116

Facial nerve paresis (FNP), a neurological disorder, affects 2.6 million people in the United States, with approximately 480,000 newly diagnosed cases due to Bell’s Palsy alone each year. Pure motor nerves, such as the facial nerve, oftentimes exhibit some form of recovery following injury; however, most suffer from mild to severe loss of motor function, which is typically seen in those who obtain FNP from a stroke. The application of neuroprosthetic devices, namely peripheral nerve interfaces, to augment endogenous function and/or regeneration (e.g., increased neuromuscular junctions) or to restore function artificially has been a successful approach in the treatment of permanent or incomplete FNP. These bioelectric technologies, including nerve cuff electrodes, have already been proved efficacious in improving paretic pathologies and are readily available and employed to treat a variety of disorders in the clinical adjunct setting. This project investigated the novel application of a readily available 8-channel monopolar nerve cuff electrode in a feline model of FNP to selectively stimulate four facial muscles (orbicularis oris, orbicularis oculi, nasalis, and levator auris longus) with direct application to facial re-animation. After analyzing EMG responses versus specific channel stimulation, channel-specific activation of the four different muscles demonstrated selectivity of nasalis and orbicularis oculi in channel 2, selectivity of only orbicularis oculi in channel 6, and selectivity of levator auris longus in channels 11 and 12. The results from this study hold promise for the development of an implantable device to selectively stimulate and activate restricted nerve fiber populations.