Presentation Title

Ellagic Acid effects B cell myeloma cells

Faculty Mentor

Sylvia Vetrone

Start Date

18-11-2017 2:15 PM

End Date

18-11-2017 3:15 PM

Location

BSC-Ursa Minor 55

Session

Poster 3

Type of Presentation

Poster

Subject Area

biological_agricultural_sciences

Abstract

B cell myeloma also known as multiple myeloma is a circulating cancer that forms from plasma cells. B cell myeloma is fairly uncommon, 1 to 143 people will have it. The cause for B cell myeloma remains unknown. Ellagic Acid is a natural antioxidant found in 46 fruits and several nuts, which has been shown to prevent cancer cells and cell proliferation. The purpose of this project was to test the effect of Ellagic Acid on B cell myeloma cell’s mortality using different concentrations of Ellagic Acid. The concentrations tested were 25uM, 45uM, and 80uM, B cell myeloma cells were kept in a 37°C in 5% CO2 incubator and Ellagic Acid was diluted with water. The results concluded that the 25uM had the highest mortality rate compared to the other concentrations with 26.18%. We also proposed that Ellagic Acid may work best on adherent cancer cells rather than suspension cells. The experiment that allowed us to concluded this was the prostate cancer cells being inhibited by Ellagic Acid at 100uM concentration, which is consistent with other multiple experiments on prostate cancer cells. As previous studies have shown that Ellagic Acid has worked on adherent cancer cells such as prostate cancer cells. Further studies are needed to determine if Ellagic Acid works on other types of suspension cancer cells (etc. macrophages, white blood cells).

Keywords: Ellagic Acid, B cell myeloma, multiple myeloma

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Nov 18th, 2:15 PM Nov 18th, 3:15 PM

Ellagic Acid effects B cell myeloma cells

BSC-Ursa Minor 55

B cell myeloma also known as multiple myeloma is a circulating cancer that forms from plasma cells. B cell myeloma is fairly uncommon, 1 to 143 people will have it. The cause for B cell myeloma remains unknown. Ellagic Acid is a natural antioxidant found in 46 fruits and several nuts, which has been shown to prevent cancer cells and cell proliferation. The purpose of this project was to test the effect of Ellagic Acid on B cell myeloma cell’s mortality using different concentrations of Ellagic Acid. The concentrations tested were 25uM, 45uM, and 80uM, B cell myeloma cells were kept in a 37°C in 5% CO2 incubator and Ellagic Acid was diluted with water. The results concluded that the 25uM had the highest mortality rate compared to the other concentrations with 26.18%. We also proposed that Ellagic Acid may work best on adherent cancer cells rather than suspension cells. The experiment that allowed us to concluded this was the prostate cancer cells being inhibited by Ellagic Acid at 100uM concentration, which is consistent with other multiple experiments on prostate cancer cells. As previous studies have shown that Ellagic Acid has worked on adherent cancer cells such as prostate cancer cells. Further studies are needed to determine if Ellagic Acid works on other types of suspension cancer cells (etc. macrophages, white blood cells).

Keywords: Ellagic Acid, B cell myeloma, multiple myeloma