Presentation Title

Lipoic Acid’s effect on the inhibition of lactase dehydrogenase

Faculty Mentor

Jerome Garcia

Start Date

18-11-2017 2:15 PM

End Date

18-11-2017 3:15 PM

Location

BSC-Ursa Minor 56

Session

Poster 3

Type of Presentation

Poster

Subject Area

biological_agricultural_sciences

Abstract

Obesity is one of the leading causes of death in the U.S. According to the Centers for Disease Control and Prevention (CDC), 37% of the adults and 17% of the youth living in the U.S. are either overweight or obese and the numbers are steadily increasing. Obesity can also lead to other costly diseases, such as cancer (Jain and Manna, 2015). Since this disease is preventable, professionals have been closely examining it to find a solution. The most common treatments are diet & exercise. Many prefer not to put physical effort into decreasing their weight and thus choose to take over-the-counter supplements like lipoic acid (LA). LA is a very popular weight loss supplement. However, there is not enough evidence to prove that the use of LA in the body is a sustainable method for weight loss and whether or not it is safe (short term and long term). Previous work in Dr. Garcia’s lab suggests LA’s mechanism for weight loss is based on the inhibition of lactate dehydrogenase (LDH). Therefore, to further examine LA and its mechanism, we measured LDH enzyme kinetics with and without LA. Through this process, we have expanded our knowledge on the inhibitory effects of LA in metabolism. We discovered that there was a difference on the inhibition of LDH when LA was added to our control.

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Nov 18th, 2:15 PM Nov 18th, 3:15 PM

Lipoic Acid’s effect on the inhibition of lactase dehydrogenase

BSC-Ursa Minor 56

Obesity is one of the leading causes of death in the U.S. According to the Centers for Disease Control and Prevention (CDC), 37% of the adults and 17% of the youth living in the U.S. are either overweight or obese and the numbers are steadily increasing. Obesity can also lead to other costly diseases, such as cancer (Jain and Manna, 2015). Since this disease is preventable, professionals have been closely examining it to find a solution. The most common treatments are diet & exercise. Many prefer not to put physical effort into decreasing their weight and thus choose to take over-the-counter supplements like lipoic acid (LA). LA is a very popular weight loss supplement. However, there is not enough evidence to prove that the use of LA in the body is a sustainable method for weight loss and whether or not it is safe (short term and long term). Previous work in Dr. Garcia’s lab suggests LA’s mechanism for weight loss is based on the inhibition of lactate dehydrogenase (LDH). Therefore, to further examine LA and its mechanism, we measured LDH enzyme kinetics with and without LA. Through this process, we have expanded our knowledge on the inhibitory effects of LA in metabolism. We discovered that there was a difference on the inhibition of LDH when LA was added to our control.