Presentation Title

Design and synthesis of asymmetric (R)-BINOL derived organocatalysts for stereoselective synthesis

Faculty Mentor

Robert Iafe

Start Date

23-11-2019 9:45 AM

End Date

23-11-2019 10:00 AM

Location

Markstein 205

Session

oral 1

Type of Presentation

Oral Talk

Subject Area

physical_mathematical_sciences

Abstract

Chemical catalysis, often by the use of rare earth metals, is an important tool for compound manipulation, not only by accelerating reactions but also by providing chemists a handle for stereoselective synthesis. Recently, there has been growing international concern over the supply of rare Earth metals. Thusly, the demand for alternatives to a potentially limited source of critical Earth metals is climbing. Additionally, nonmetal-, or organo-, catalysts offer an alternative to reactions that work with toxic metals. (R)-BINOL is an organocatalyst scaffold used to make chiral catalysts with as well as without metals. Herein we designed a series of asymmetric (R)-BINOL derived organocatalysts for stereoselective catalysis. Current progress through the third intermediate has achieved acceptable product yields ranging from 70-96%. All compounds have been characterized using 1HNMR, and 13CNMR, and all novel compounds are planned to be characterized by FT-IR and GCMS.

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Nov 23rd, 9:45 AM Nov 23rd, 10:00 AM

Design and synthesis of asymmetric (R)-BINOL derived organocatalysts for stereoselective synthesis

Markstein 205

Chemical catalysis, often by the use of rare earth metals, is an important tool for compound manipulation, not only by accelerating reactions but also by providing chemists a handle for stereoselective synthesis. Recently, there has been growing international concern over the supply of rare Earth metals. Thusly, the demand for alternatives to a potentially limited source of critical Earth metals is climbing. Additionally, nonmetal-, or organo-, catalysts offer an alternative to reactions that work with toxic metals. (R)-BINOL is an organocatalyst scaffold used to make chiral catalysts with as well as without metals. Herein we designed a series of asymmetric (R)-BINOL derived organocatalysts for stereoselective catalysis. Current progress through the third intermediate has achieved acceptable product yields ranging from 70-96%. All compounds have been characterized using 1HNMR, and 13CNMR, and all novel compounds are planned to be characterized by FT-IR and GCMS.