Presentation Title

Increase Acupuncture Effect with Targeted Electroacupuncture Treatment

Faculty Mentor

Stephanie Tjen-A-Looi

Start Date

23-11-2019 8:45 AM

End Date

23-11-2019 9:00 AM

Location

Markstein 308

Session

oral 1

Type of Presentation

Oral Talk

Subject Area

health_nutrition_clinical_science

Abstract

Elderly patients display chronic low-grade inflammation due to aging and contribute to the pathogenesis of essential hypertension. Dysfunctional neuroendocrine and immune mechanisms underlying increased blood pressure (BP) in elderly individuals are not targeted by existing pharmacological therapies due to side effects. Electroacupuncture (EA) stimulates somatosensory nerves that underlie specific acupoints and contribute to a long-lasting inhibitory effect in long-loop neural pathways. In preliminary studies, EA twice a week at ST 36-37 (SI-EA) that underlies the deep peroneal nerve has shown to reduce blood pressure in Dahl salt-sensitive (DSS) hypertensive (HTNive) rats with sympathoinhibition. EA twice a week at Sp6-7 (AI-EA) that underlie the tibial nerve has shown decreased blood pressure through activated neurons in the nucleus tractus solitarius (NTS) and dorsal motor nucleus of the vagus nerve (DMV) and decreased inflammatory biomarker hs-CRP by the muscarinic cholinergic system in DSS HTNive rats. We hypothesize that the synergism of combined EA (SI-EA and AI-EA) reduces blood pressure in HTNive rats than either SI-EA or AI-EA alone by decreasing sympathetic tone and inflammation. 24 DSS rats were allocated into three different treatment groups: combined EA, sham-combined EA, and non-treated normotensive rats. BP, NTS/DMV activity, inflammation in circulation and brain tissues were evaluated in these three groups by observations of neuronal activation with immunohistochemical (IHC) staining and blood collection. Twice a week of EA treatments at ST 36-37 or Sp6-7 decreased BP in comparison to sham-EAs in DSS HTNive rats. Combined SI-EA and AI-EA display further decreased in BP. These findings suggest the synergism of BP reduction in DSS HTNive rats treated with combined EA compared to SI-EA and AI-EA alone and that the combined EA treatment poses as a possible non-pharmacological method of reducing blood pressure and chronic inflammation in elderly patients.

Keywords: Electroacupuncture, Blood Pressure, Acupoints ST36-37 and Sp6-7, Inflammation, Hypertension

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Nov 23rd, 8:45 AM Nov 23rd, 9:00 AM

Increase Acupuncture Effect with Targeted Electroacupuncture Treatment

Markstein 308

Elderly patients display chronic low-grade inflammation due to aging and contribute to the pathogenesis of essential hypertension. Dysfunctional neuroendocrine and immune mechanisms underlying increased blood pressure (BP) in elderly individuals are not targeted by existing pharmacological therapies due to side effects. Electroacupuncture (EA) stimulates somatosensory nerves that underlie specific acupoints and contribute to a long-lasting inhibitory effect in long-loop neural pathways. In preliminary studies, EA twice a week at ST 36-37 (SI-EA) that underlies the deep peroneal nerve has shown to reduce blood pressure in Dahl salt-sensitive (DSS) hypertensive (HTNive) rats with sympathoinhibition. EA twice a week at Sp6-7 (AI-EA) that underlie the tibial nerve has shown decreased blood pressure through activated neurons in the nucleus tractus solitarius (NTS) and dorsal motor nucleus of the vagus nerve (DMV) and decreased inflammatory biomarker hs-CRP by the muscarinic cholinergic system in DSS HTNive rats. We hypothesize that the synergism of combined EA (SI-EA and AI-EA) reduces blood pressure in HTNive rats than either SI-EA or AI-EA alone by decreasing sympathetic tone and inflammation. 24 DSS rats were allocated into three different treatment groups: combined EA, sham-combined EA, and non-treated normotensive rats. BP, NTS/DMV activity, inflammation in circulation and brain tissues were evaluated in these three groups by observations of neuronal activation with immunohistochemical (IHC) staining and blood collection. Twice a week of EA treatments at ST 36-37 or Sp6-7 decreased BP in comparison to sham-EAs in DSS HTNive rats. Combined SI-EA and AI-EA display further decreased in BP. These findings suggest the synergism of BP reduction in DSS HTNive rats treated with combined EA compared to SI-EA and AI-EA alone and that the combined EA treatment poses as a possible non-pharmacological method of reducing blood pressure and chronic inflammation in elderly patients.

Keywords: Electroacupuncture, Blood Pressure, Acupoints ST36-37 and Sp6-7, Inflammation, Hypertension