Presentation Title

Effects of Astrocytic Ephrin-B1 on Synapse Formation in Developing Hippocampus

Faculty Mentor

Iryna Ethell, PhD

Start Date

23-11-2019 1:30 PM

End Date

23-11-2019 1:45 PM

Location

Markstein 210

Session

oral 3

Type of Presentation

Oral Talk

Subject Area

biological_agricultural_sciences

Abstract

Abstract: Astrocytes are glial cells in the brain that are key participants in brain development and function. Astrocytes control formation of functional synaptic connections in the brain, making them a target for controlling neuronal circuits and associated behaviors. Although the role of astrocyte-derived secreted factors in synaptogenesis is well accepted, astrocytic contacts with neurons can direct synapse formation and elimination through yet unknown mechanisms. Our previous study suggests that the changes in ephrin-B1 levels in astrocytes may influence trans-synaptic interaction between neuronal ephrin and its EphB receptors, affecting synapse formation in vitro. In this study, we examined whether the deletion of astrocytic ephrin-B1 during postnatal development (P14-P28) would affect synapse formation and maturation in the developing hippocampus in vivo. Our data show that loss of astrocytic ephrin-B1 enhances excitatory synapse formation and hyperexcitability, which may lead to hyperexcitable and anxious behaviors, and enhance susceptibility to seizures.

Keywords: Astrocytes, Synapse, Hippocampus, Ephrin-B1

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Nov 23rd, 1:30 PM Nov 23rd, 1:45 PM

Effects of Astrocytic Ephrin-B1 on Synapse Formation in Developing Hippocampus

Markstein 210

Abstract: Astrocytes are glial cells in the brain that are key participants in brain development and function. Astrocytes control formation of functional synaptic connections in the brain, making them a target for controlling neuronal circuits and associated behaviors. Although the role of astrocyte-derived secreted factors in synaptogenesis is well accepted, astrocytic contacts with neurons can direct synapse formation and elimination through yet unknown mechanisms. Our previous study suggests that the changes in ephrin-B1 levels in astrocytes may influence trans-synaptic interaction between neuronal ephrin and its EphB receptors, affecting synapse formation in vitro. In this study, we examined whether the deletion of astrocytic ephrin-B1 during postnatal development (P14-P28) would affect synapse formation and maturation in the developing hippocampus in vivo. Our data show that loss of astrocytic ephrin-B1 enhances excitatory synapse formation and hyperexcitability, which may lead to hyperexcitable and anxious behaviors, and enhance susceptibility to seizures.

Keywords: Astrocytes, Synapse, Hippocampus, Ephrin-B1