Presentation Title

Different stimulation modalities at acupoint ST36 decrease blood pressure differentially: TRPV1

Faculty Mentor

Stephanie Tjen-A-Looi

Start Date

23-11-2019 12:30 PM

End Date

23-11-2019 12:45 PM

Location

Markstein 306

Session

oral 3

Type of Presentation

Oral Talk

Subject Area

health_nutrition_clinical_science

Abstract

Hypertension, defined as blood pressure (BP) above 120/80 mmHg, can lead to stroke or heart disease if left untreated. With it being such a prevalent issue, treatments besides prescription medications could benefit the lives of many. Alternative treatments include manual acupuncture (MA), electroacupuncture (EA), and moxibustion (MOXI), which all have different peripheral mechanisms for lowering elevated BP.

Transient receptor potential vanilloid type-1 (TRPV1) is a polymodal receptor that is present in the region of acupoints in the deep peroneal nerve (ST36-37) and is activated by natural stimuli like heat and mechanical stimulation. EA is unable to stimulate the deep peroneal nerve through the TRPV1 receptor; rather, it stimulates through C and A-delta fibers. We hypothesize that TRPV1 works to peripherally reduce elevated BP in only MA and MOXI.

MA is administered through stimulating the deep peroneal nerve by twisting an acupuncture needle at ST36. EA differs from MA in that weak electrical currents are applied to two needles at the ST36-37 acupoints. During MOXI, a moxa stick is held one centimeter away from ST36, maintaining a temperature of 44.2 ± 0.6◦C at the acupoint. All three modalities significantly decrease BP through stimulation of the deep peroneal nerve; however, the mechanisms underlying acupuncture stimulation of the nerve are different.

The data presented showed that, in contrast to the control, blockade of the TRPV1 receptor with antagonist iodoresiniferatoxin (Iodo-RTX) reversed the inhibition of elevations in BP after MOXI and MA treatments, but was unable to have the same effect in EA. Since BP was unaffected by Iodo-RTX in the EA model, we know that the TRPV1 receptor is not involved in the inhibitory peripheral mechanism of EA. With TRPV1 being involved in the mechanisms of both MA and MOXI, it is important in acupuncture modulation of cardiovascular responses.

Keywords: heat sensitive, TRVP1, mechanosensitive, reflex hypertension, sympathoexcitation, acupuncture, moxibustion

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Nov 23rd, 12:30 PM Nov 23rd, 12:45 PM

Different stimulation modalities at acupoint ST36 decrease blood pressure differentially: TRPV1

Markstein 306

Hypertension, defined as blood pressure (BP) above 120/80 mmHg, can lead to stroke or heart disease if left untreated. With it being such a prevalent issue, treatments besides prescription medications could benefit the lives of many. Alternative treatments include manual acupuncture (MA), electroacupuncture (EA), and moxibustion (MOXI), which all have different peripheral mechanisms for lowering elevated BP.

Transient receptor potential vanilloid type-1 (TRPV1) is a polymodal receptor that is present in the region of acupoints in the deep peroneal nerve (ST36-37) and is activated by natural stimuli like heat and mechanical stimulation. EA is unable to stimulate the deep peroneal nerve through the TRPV1 receptor; rather, it stimulates through C and A-delta fibers. We hypothesize that TRPV1 works to peripherally reduce elevated BP in only MA and MOXI.

MA is administered through stimulating the deep peroneal nerve by twisting an acupuncture needle at ST36. EA differs from MA in that weak electrical currents are applied to two needles at the ST36-37 acupoints. During MOXI, a moxa stick is held one centimeter away from ST36, maintaining a temperature of 44.2 ± 0.6◦C at the acupoint. All three modalities significantly decrease BP through stimulation of the deep peroneal nerve; however, the mechanisms underlying acupuncture stimulation of the nerve are different.

The data presented showed that, in contrast to the control, blockade of the TRPV1 receptor with antagonist iodoresiniferatoxin (Iodo-RTX) reversed the inhibition of elevations in BP after MOXI and MA treatments, but was unable to have the same effect in EA. Since BP was unaffected by Iodo-RTX in the EA model, we know that the TRPV1 receptor is not involved in the inhibitory peripheral mechanism of EA. With TRPV1 being involved in the mechanisms of both MA and MOXI, it is important in acupuncture modulation of cardiovascular responses.

Keywords: heat sensitive, TRVP1, mechanosensitive, reflex hypertension, sympathoexcitation, acupuncture, moxibustion