Presentation Title

Long-lasting and Short-Lasting Effects of Moxibustion at ST 36 on Sustained Hypertension

Faculty Mentor

Stephanie Tjen-A-Looi

Start Date

23-11-2019 1:30 PM

End Date

23-11-2019 1:45 PM

Location

Markstein 306

Session

oral 3

Type of Presentation

Oral Talk

Subject Area

health_nutrition_clinical_science

Abstract

Hypertension serves to be one of the major risk factors that contributes to cardiovascular diseases. Electroacupuncture (EA) at acupoints ST36-37 reduces elevated blood pressure in both the reflex and sustained hypertension in animal and human. The inhibition of the sympathoexcitatory reflex response is from an opioid mechanism in the CNS notably through the paraventricular nucleus (PVN) and rostral ventrolateral medulla (rVLM). Moxibustion at ST36 also reduces sympathoexcitatory cardiovascular reflex responses (reflex elevated blood pressure) by the activation of opioid receptors within the hypothalamic PVN. In hypertensive conscious rats, preliminary data showed a negative chronotropic effect with moxibustion at ST36 suggesting that the parasympathetic system could be involved such as the nucleus tractus solitarius (NTS). The effects of moxibustion on blood pressure and heart rate in a sustained hypertension model have not been fully investigated. I hypothesize that moxibustion at ST36 on sustained hypertension leads to both a short-lasting and long-lasting attenuation of blood pressure and heart rate through activation of the NTS. Moxibustion was administered 3 times a week at acupoint ST36 in hypertensive rats. Moxibustion sticks were held 1-cm away from the skin and temperature was taken to maintain a consistent temperature of 44.2°C. Immunohistochemistry was performed to evaluate the activation (c-Fos expression) of neurons in the NTS. The data showed that moxibustion at ST36 modulated blood pressure and heart rate in two ways: 1) for 24 hours following each treatment 2) after 5 weeks of repeated moxibustion given three times a week in sustained hypertensive rats.

Key Words:

Hypertension, Moxibustion, Electroacupuncture, ST 36 Acupoint, Immunohistochemistry, c-Fos expression, paraventricular nucleus, rostral ventrolateral medulla, nucleus tractus solitarius

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Nov 23rd, 1:30 PM Nov 23rd, 1:45 PM

Long-lasting and Short-Lasting Effects of Moxibustion at ST 36 on Sustained Hypertension

Markstein 306

Hypertension serves to be one of the major risk factors that contributes to cardiovascular diseases. Electroacupuncture (EA) at acupoints ST36-37 reduces elevated blood pressure in both the reflex and sustained hypertension in animal and human. The inhibition of the sympathoexcitatory reflex response is from an opioid mechanism in the CNS notably through the paraventricular nucleus (PVN) and rostral ventrolateral medulla (rVLM). Moxibustion at ST36 also reduces sympathoexcitatory cardiovascular reflex responses (reflex elevated blood pressure) by the activation of opioid receptors within the hypothalamic PVN. In hypertensive conscious rats, preliminary data showed a negative chronotropic effect with moxibustion at ST36 suggesting that the parasympathetic system could be involved such as the nucleus tractus solitarius (NTS). The effects of moxibustion on blood pressure and heart rate in a sustained hypertension model have not been fully investigated. I hypothesize that moxibustion at ST36 on sustained hypertension leads to both a short-lasting and long-lasting attenuation of blood pressure and heart rate through activation of the NTS. Moxibustion was administered 3 times a week at acupoint ST36 in hypertensive rats. Moxibustion sticks were held 1-cm away from the skin and temperature was taken to maintain a consistent temperature of 44.2°C. Immunohistochemistry was performed to evaluate the activation (c-Fos expression) of neurons in the NTS. The data showed that moxibustion at ST36 modulated blood pressure and heart rate in two ways: 1) for 24 hours following each treatment 2) after 5 weeks of repeated moxibustion given three times a week in sustained hypertensive rats.

Key Words:

Hypertension, Moxibustion, Electroacupuncture, ST 36 Acupoint, Immunohistochemistry, c-Fos expression, paraventricular nucleus, rostral ventrolateral medulla, nucleus tractus solitarius