Presentation Title

The Pharmacogenetics of Cytochrome P450 2D6 and its Effects on Antidepressant Response Across Multiple Ethnic Backgrounds

Faculty Mentor

Kristine Arquero

Start Date

23-11-2019 8:00 AM

End Date

23-11-2019 8:45 AM

Location

255

Session

poster 1

Type of Presentation

Poster

Subject Area

physical_mathematical_sciences

Abstract

Major Depressive Disorder is one of the most common mental illnesses globally and one of the top five leading diseases for a poor quality of life which means antidepressants are constantly being sought after. However, antidepressant success rates in patients vary. The purpose of this study was to analyze ethnic groups’ levels of CYP2D6 to determine the type of metabolizer they are and to further analyze their predicted response to antidepressant medication. CYP2D6 is an enzyme responsible for metabolizing certain drugs in the human body. Results of one study showed that there are four types of metabolizers and, an individual’s ethnicity has some influence on the type of metabolizer they are. Each type of metabolizer responds differently to antidepressants which affects the amount and type of antidepressant an individual should be prescribed and consume. In another study, antidepressant usage and history was analyzed to supplement the data on CYP2D6 to see how antidepressant response and usage has evolved over time. From reviewing multiple studies, research indicates that antidepressant response in patients is linked to the CYP2D6 enzyme which is also interconnected with ethnicity. Clinicians can learn about the concentration of the CYP2D6 enzyme in an individual to determine the type of metabolizer they are and prescribe them the proper dosage of an antidepressant. Prescriptions that are based around the metabolic rate of a patient can benefit the medical field by ensuring that patients are successfully treated as they would exhibit a satisfactory therapeutic response to the medication.

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Nov 23rd, 8:00 AM Nov 23rd, 8:45 AM

The Pharmacogenetics of Cytochrome P450 2D6 and its Effects on Antidepressant Response Across Multiple Ethnic Backgrounds

255

Major Depressive Disorder is one of the most common mental illnesses globally and one of the top five leading diseases for a poor quality of life which means antidepressants are constantly being sought after. However, antidepressant success rates in patients vary. The purpose of this study was to analyze ethnic groups’ levels of CYP2D6 to determine the type of metabolizer they are and to further analyze their predicted response to antidepressant medication. CYP2D6 is an enzyme responsible for metabolizing certain drugs in the human body. Results of one study showed that there are four types of metabolizers and, an individual’s ethnicity has some influence on the type of metabolizer they are. Each type of metabolizer responds differently to antidepressants which affects the amount and type of antidepressant an individual should be prescribed and consume. In another study, antidepressant usage and history was analyzed to supplement the data on CYP2D6 to see how antidepressant response and usage has evolved over time. From reviewing multiple studies, research indicates that antidepressant response in patients is linked to the CYP2D6 enzyme which is also interconnected with ethnicity. Clinicians can learn about the concentration of the CYP2D6 enzyme in an individual to determine the type of metabolizer they are and prescribe them the proper dosage of an antidepressant. Prescriptions that are based around the metabolic rate of a patient can benefit the medical field by ensuring that patients are successfully treated as they would exhibit a satisfactory therapeutic response to the medication.