Presentation Title

Activation of Biologically Relevant Organic Acids

Faculty Mentor

Asmik Oganesyan

Start Date

23-11-2019 8:00 AM

End Date

23-11-2019 8:45 AM

Location

259

Session

poster 1

Type of Presentation

Poster

Subject Area

physical_mathematical_sciences

Abstract

It has been established that carboxylic acid and their derivatives play an important role in biological processes. It has been shown in the literature that amides of some carboxylic acids exhibit antioxidant, anti-inflammatory, and antibacterial activity. However, synthesis of the derivatives entail the activation of carboxylic acids, which is a challenging procedure. In this research, we investigated synthetic and purification routes of several aromatic and aliphatic carboxylic acids. DCC (N, N'- dicyclohexylcarbodiimide) is used as an activating reagent to produce N- hydroxysuccinimide derivatives of these carboxylic acids. The compounds were characterized by IR and H NMR. All of our activated carboxylic acids are crystalline, easy to store, and are used to further convert the acids into biologically active amides. These derivatives can be utilized to synthesize small dendrimers carrying multiple biologically relevant payloads.

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Nov 23rd, 8:00 AM Nov 23rd, 8:45 AM

Activation of Biologically Relevant Organic Acids

259

It has been established that carboxylic acid and their derivatives play an important role in biological processes. It has been shown in the literature that amides of some carboxylic acids exhibit antioxidant, anti-inflammatory, and antibacterial activity. However, synthesis of the derivatives entail the activation of carboxylic acids, which is a challenging procedure. In this research, we investigated synthetic and purification routes of several aromatic and aliphatic carboxylic acids. DCC (N, N'- dicyclohexylcarbodiimide) is used as an activating reagent to produce N- hydroxysuccinimide derivatives of these carboxylic acids. The compounds were characterized by IR and H NMR. All of our activated carboxylic acids are crystalline, easy to store, and are used to further convert the acids into biologically active amides. These derivatives can be utilized to synthesize small dendrimers carrying multiple biologically relevant payloads.