Presentation Title

Synthesis of Metal-Organic Frameworks

Faculty Mentor

Jesus Cordova Guerrero Ph.D

Start Date

23-11-2019 10:00 AM

End Date

23-11-2019 10:45 AM

Location

257

Session

poster 3

Type of Presentation

Poster

Subject Area

physical_mathematical_sciences

Abstract

The purpose of this research is to synthesize a metal-organic framework (MOF) designed to store and release a pseudo drug. In the MOF synthesis, the first step is the formation of the organic linker. The inexpensive and commercially available starting material will be transformed into a p-terphenyl carboxylate organic linker with a pseudo drug (substituted coumarin) attached to the central phenyl ring. The second step is the formation of the MOF, by bonding metal clusters to the organic linkers. The final step is the release of the pseudo drug through a free radical mechanism driven by high energy light. The results achieved thus far are the reactions leading to the near completion of the para-terphenyl organic linker with the pseudo drug attached. In the future, the MOF will be formed by attaching the metal clusters to the organic linkers and the pseudo drug will be released through activation of the MOF with high energy light. The goals of this research are to complete the MOF and release the pseudo drug.

Keywords:

Metal-organic framework: a hybrid organic-inorganic crystalline porous material repeating framework consisting of organic linkers connected by metal clusters. This material has high volume and is able to capture, store, and release molecules.

Pseudo drug: a model drug system, in this case 6-hydroxy coumarin.

P-terphenyl: three phenyl rings attached end to end in a chain.

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Nov 23rd, 10:00 AM Nov 23rd, 10:45 AM

Synthesis of Metal-Organic Frameworks

257

The purpose of this research is to synthesize a metal-organic framework (MOF) designed to store and release a pseudo drug. In the MOF synthesis, the first step is the formation of the organic linker. The inexpensive and commercially available starting material will be transformed into a p-terphenyl carboxylate organic linker with a pseudo drug (substituted coumarin) attached to the central phenyl ring. The second step is the formation of the MOF, by bonding metal clusters to the organic linkers. The final step is the release of the pseudo drug through a free radical mechanism driven by high energy light. The results achieved thus far are the reactions leading to the near completion of the para-terphenyl organic linker with the pseudo drug attached. In the future, the MOF will be formed by attaching the metal clusters to the organic linkers and the pseudo drug will be released through activation of the MOF with high energy light. The goals of this research are to complete the MOF and release the pseudo drug.

Keywords:

Metal-organic framework: a hybrid organic-inorganic crystalline porous material repeating framework consisting of organic linkers connected by metal clusters. This material has high volume and is able to capture, store, and release molecules.

Pseudo drug: a model drug system, in this case 6-hydroxy coumarin.

P-terphenyl: three phenyl rings attached end to end in a chain.